Results 251 to 260 of about 345,005 (304)

Complement and complement inhibitors

Current Opinion in Nephrology and Hypertension, 1998
The role of complement in the pathogenesis of renal injury is now being confirmed with the use of knockout technology and specific inhibitors. Chronic injury, particularly of the tubules and interstitium, and local complement synthesis are emerging as potential additional targets for complement-based therapy.
N S, Sheerin, S H, Sacks
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Novel complement inhibitors

Expert Opinion on Investigational Drugs, 1998
The complement system provides natural immunity against microbes and is an effector arm of antibody-mediated humoral immunity. It promotes the inflammatory process by activating cells and facilitates microbial destruction through opsonisation and lysis.
M K, Liszewski, J P, Atkinson
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Microbial complement inhibitors as vaccines

Vaccine, 2008
Complement inhibiting surface proteins of pathogenic bacteria provide candidates for vaccines because of two reasons. First, an immune response against them would recognize the microbes and secondly, it would neutralize the key bacterial virulence mechanism.
Seppo, Meri, Markus, Jördens, Hanna, Jarva   +2 more
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Candidate inhibitors of porcine complement

Molecular Immunology, 2007
Therapeutic complement inhibition is a promising strategy for treatment of a number of diseases as judged from rodent studies. The species distance from rodents to humans may limit the clinical relevance of these studies. The pig is an alternative animal for studies of human diseases like sepsis and ischemia/reperfusion injury.
Ebbe B, Thorgersen, Yohannes T, Ghebremariam, Joshua M, Thurman, Michael, Fung, Erik Waage, Nielsen, V Michael, Holers, Girish J, Kotwal, Tom Eirik, Mollnes   +7 more
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New inhibitors of complement fixation

Immunopharmacology, 1981
A search for compounds that inhibit complement fixation revealed a number of new inhibitors. The presence of EDTA in the phosphate buffer containing complement and compound aided in the detection of compounds that inhibit complement fixation. Compounds were identified as inhibitors that previously could not be shown experimentally to inhibit complement
M, Lapidus, J, Tomasco
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Membrane-targeted complement inhibitors

Molecular Immunology, 2001
Undesirable complement activation contributes to the pathology of many human diseases by damaging tissue and promoting inflammation. Because complement-mediated damage is caused by the deposition of complement components on the cell surface, several strategies have been devised to target complement regulator proteins to cell membranes. These strategies
Smith, G P, Smith, R A G
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Thanks for the complement (inhibitor)

Blood, 2011
Developing an effective inhibitor of the alternative pathway of complement (APC) with potential for safe clinical use is a daunting undertaking, but Fridkis-Hareli and colleagues were up for the challenge.[1][1] The straightforward strategy of generating an antibody that inhibits complement C3 ...
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Activators and Inhibitors of Complement

Annals of Oncology, 1993
1. The Complement System.- 2. The Structure of Immunoglobulins and Their Interaction with Complement.- 3. Non-Immunoglobulin Activators of the Complement System.- 4. Solid Phase Activators of the Alternative Pathway of Complement and Their Use in vivo.- 5. Nucleophilic Compounds Acting on C3 and C4.- 6.
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Systematic discovery and evaluation of complement inhibitors

Immunopharmacology, 1981
Methods are presented for an orderly search of a chemical file for complement inhibitors. Compounds are initially examined for intrinsic activity against dilute human components in vitro, using hemolytic assays to detect inhibitors of fluid phase C1, of late components lysis of EAC142, and of CVF-induced passive lysis of AET-treated human erythrocytes.
N, Bauman, J A, Brockman, B S, Pease, W J, Elliott, D F, Colucci   +4 more
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