Results 1 to 10 of about 102,836 (39)

Gain-of-Function Mutations R249C and S250C in Complement C2 Protein Increase C3 Deposition in the Presence of C-Reactive Protein [PDF]

, 2021
The impairment of the alternative complement pathway contributes to rare kidney diseases such as atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G).
Alonso, Eugenia Castellote, Arjona, Emilia, Fenollosa Segarra, María Ángeles, Jongerius, Ilse, Kowalska, Daria, Kuźniewska, Alicja, Okrój, Marcin, Ołdziej, Stanisław, Rodriguez de Córdoba, Santiago, Satchell, Simon, Skrobińska, Anna, Spaapen, Robbert, Stasiłojć, Grzegorz, Thiel, Marcel, Urban, Aleksandra   +14 more
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Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex [PDF]

, 2016
Citation: Garcia, B. L., Zhi, H., Wager, B., Hook, M., & Skare, J. T. (2016). Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex. Plos Pathogens, 12(1), 28.
A Alitalo, A Hubner, A Roos, A Sadziene, A Sadziene, AE Davis 3rd, AG Barbour, AP van Dam, B Major, Beau Wager, BK Boardman, Brandon L. Garcia, BV Geisbrecht, C Gaboriaud, CA Brissette, CJ Hastey, CS Brooks, D Ricklin, D Ricklin, D. Scott Samuels, DS Samuels, E Fikrig, EA Rogers, EA Rogers, EH Weening, ER Lewis, G Harris, G Stanek, Girija U Venkatraman, H Zhi, Hui Zhi, I Bally, J Hellwage, J Pietikainen, J Schwab, J Seshu, JA Caine, JA Hyde, JD Lambris, JD Radolf, JH Kim, Jon T. Skare, JR Fischer, JV McDowell, JV McDowell, K Kurtenbach, KM Hovis, LK Bockenstedt, LY Lee, M Hammel, M He, M Jozsi, M Labandeira-Rey, M Pausa, Magnus Höök, MB Lawrenz, MC Carroll, MC Carroll, ME Woodman, MJ Caimano, MN Burtnick, MR Kenedy, MR Kenedy, MU Norman, NA Meenan, NM Thielens, P Kraiczy, P Kraiczy, PF Zipfel, R Wallis, RA Elsner, RA Gaultney, RJ Bingham, RJ Ziccardi, RJ Ziccardi, S Grosskinsky, S Prabhakaran, S Raibaud, S Thiel, SK Kochi, SW de Taeye, T Bykowski, T Hallstrom, T Hallstrom, T Meri, TF Busby, TJ Moriarty, U Schwarz-Linek, UK Laemmli, V Cook, WK Ip, WS Probert, WS Probert, WS Probert, X Li, X Yang, XF Yang, Y Wu, YP Ko, YP Ko, YP Lin, ZR Marjenberg   +101 more
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The classical pathway triggers pathogenic complement activation in membranous nephropathy [PDF]

, 2023
Membranous nephropathy (MN) is an antibody-mediated autoimmune disease characterized by glomerular immune complexes containing complement components. However, both the initiation pathways and the pathogenic significance of complement activation in MN are
Biniaminov, Sergey, Borodovsky, Anna, Cheng, Hong, Dehde, Silke, Froembling, Sarah, Hickstein, Naemi, Hopfer, Helmut, Huber, Tobias B., Koch-Nolte, Friedrich, Kretz, Oliver, Kylies, Dominik, Köllner, Sarah M. S., Lucas, Renke, Meyer-Schwesinger, Catherine, Panzer, Ulf, Puelles, Victor G., Seifert, Larissa, Tomas, Nicola M., Wang, Yanyan, Wiech, Thorsten, Wulf, Sonia, Zahner, Gunther, Zielinski, Stephanie, Zipfel, Peter F.   +23 more
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Paths reunited: initiation of the classical and lectin pathways of complement activation [PDF]

, 2010
Understanding the structural organisation and mode of action of the initiating complex of the classical pathway of complement activation (C1) has been a central goal in complement biology since its isolation almost 50 years ago.
Keeble, Anthony H., Mitchell, Daniel A., Schmid, Ralf, Schwaeble, Wilhelm J., Wallis, Russell   +4 more
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SALO, a novel classical pathway complement inhibitor from saliva of the sand fly Lutzomyia longipalpis. [PDF]

, 2016
Blood-feeding insects inject potent salivary components including complement inhibitors into their host's skin to acquire a blood meal. Sand fly saliva was shown to inhibit the classical pathway of complement; however, the molecular identity of the ...
Abdeladhim, M., Brandt, E.A., Collin, N., Coutinho-Abreu, I.V., Fazito Vale, V., Ferreira Mendes-Sousa, A., Ferreira, V.P., Gontijo, N.F., Horácio Pereira, M., Kamhawi, S., Kotsyfakis, M., Lima, K.F., Meneses, C., Nascimento Araújo, R., Oliveira, F., Pangburn, M.K., Rasouli, M., Ribeiro, J.M., Valenzuela, J.G.   +18 more
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Successful pharmacological intervention at different levels of the complement system in an in vitro complement fixation model for bullous pemphigoid [PDF]

, 2023
Bullous pemphigoid (BP) is characterized by deposition of immunoglobulins and complement along the epidermal basement membrane (BM). In humans, there is a lack of functional studies targeting the complement system (CS). This study investigates activation
Damman, Jeffrey, de Cordoba, Santiago Rodriguez, Diercks, Gilles F.H., Giang, Jenny, Poppelaars, Felix, Schreurs, Marco W.J., van den Bosch, Thierry P.P., van Doorn, Martijn B.A.   +7 more
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Serum amyloid P aids complement-mediated immunity to Streptococcus pneumoniae [PDF]

, 2007
The physiological functions of the acute phase protein serum amyloid P (SAP) component are not well defined, although they are likely to be important, as no natural state of SAP deficiency has been reported.
Botto, M., Bottoms, S.E., Brown, J.S., Yuste, J.   +3 more
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Complement activation and protein adsorption by carbon nanotubes [PDF]

, 2006
As a first step to validate the use of carbon nanotubes as novel vaccine or drug delivery devices, their interaction with a part of the human immune system, complement, has been explored.
Flahaut, Emmanuel, Green, Malcolm L. H., Salvador-Morales, Carolina, Sim, Edith, Sim, Robert B., Sloan, Jeremy   +5 more
core   +2 more sources

Innate immune humoral factors, C1q and factor H, with differential pattern recognition properties, alter macrophage response to carbon nanotubes [PDF]

, 2015
Interaction between the complement system and carbon nanotubes (CNTs) can modify their intended biomedical applications. Pristine and derivatised CNTs can activate complement primarily via the classical pathway which enhances uptake of CNTs and ...
Ali-Boucetta, Andersen, Andersen, Andersen, Anthony G. Tsolaki, Balavoine, Basudev Paudyal, Bennie ten Haken, Bianco, Boncel, Cardoso, Carroll, Dumortier, Gaboriaud, Gadjeva, Ghai, Gudrun Stenbeck, Hamad, Haseeb A. Khan, Heister, Heister, Hussain, Jain, Ji, Kagan, Kang, Kirsten M. Pondman, Kishore, Kishore, Kishore, Kishore, Kojouharova, Kouser, Kouser, Lee, Li, Li, Lina Pednekar, Ling, Liu, Lubna Kouser, McDevitt, Moghimi, Mohamed H. Shamji, Muller, Pan, Pantarotto, Pondman, Pondman, Pondman, Pulskamp, Robert B. Sim, Roumenina, Russier, Rybak-Smith, Rybak-Smith, Rybak-Smith, Salvador-Morales, Salvador-Morales, Salvador-Morales, Shi, Sim, Singh, Tan, Tan, Uday Kishore, Verdejo, Wick, Xiao, Zhao, Zolnik   +70 more
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The Role of Salivary and Intestinal Complement System Inhibitors in the Midgut Protection of Triatomines and Mosquitoes [PDF]

, 2009
Saliva of haematophagous arthropods contain biomolecules involved directly or indirectly with the haematophagy process, and among them are encountered some complement system inhibitors.
André Miranda Cadete, Jéssica Góes Assumpção, Marcos Horácio Pereira, Nelder Figueiredo Gontijo, Patricia Bozza, Reginaldo Roris Cavalcante, Ricardo Nascimento Araújo, Veruska Cavalcanti Barros, Vânia Cristina Santos   +8 more
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