As in Real Estate, Location Matters: Cellular Expression of Complement Varies Between Macular and Peripheral Regions of the Retina and Supporting Tissues. [PDF]
, 2022 The cellular events that dictate the initiation of the complement pathway in ocular degeneration, such as age-related macular degeneration (AMD), is poorly understood.
Biber, Josef +21 more
core +2 more sources
Complement activation by carbon nanotubes and its influence on the phagocytosis and cytokine response by macrophages [PDF]
, 2014 Carbon nanotubes (CNTs) have promised a range of applications in biomedicine. Although influenced by the dispersants used, CNTs are recognized by the innate immune system, predominantly by the classical pathway of the complement system.
Flahaut, E. +9 more
core +1 more source
Complement protein levels in plasma astrocyte-derived exosomes are abnormal in conversion from mild cognitive impairment to Alzheimer's disease dementia. [PDF]
, 2019 IntroductionLevels of complement proteins (CPs) in plasma astrocyte-derived exosomes (ADEs) that are abnormal in Alzheimer's disease (AD) have not been assessed in mild cognitive impairment (MCI).MethodsParticipants (n = 20 per group) had either MCI ...
Elahi, Fanny M +4 more
core +2 more sources
Preanalytical classical and alternative complement pathway activity loss [PDF]
, 2019 Introduction: Complement functional analyses provide insight into the integrity of the entire complement reaction cascade. These tests are suitable for investigating suspected complement deficiencies.
Joris Delanghe +2 more
core +2 more sources
Alterations in the complement cascade in post-traumatic stress disorder [PDF]
, 2010 Background In the present study we assessed the functional state of the major mediator of the immune response, the complement system, in post-traumatic stress disorder (PTSD).
Boyajyan, Anna S +3 more
core +3 more sources
A Hierarchical Role for Classical Pathway Complement Proteins in the Clearance of Apoptotic Cells in Vivo [PDF]
, 2000 The strongest susceptibility genes for the development of systemic lupus erythematosus (SLE) in humans are null mutants of classical pathway complement proteins. There is a hierarchy of disease susceptibility and severity according to the position of the
Aderem +42 more
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Analysis of C4 and the C4 binding protein in the MRL/lpr mouse [PDF]
, 2007 Systemic lupus erythematosus is a complement-mediated autoimmune disease. While genetic deficiencies of classical pathway components lead to an increased risk of developing systemic lupus erythematosus, end organ damage is associated with complement ...
Braun, Michael C +3 more
core +2 more sources
Complement-mediated kidney diseases [PDF]
, 2020 It has long been known that the complement cascade is activated in various forms of glomerulonephritis. In many of these diseases, immune-complexes deposit in the glomeruli and activate the classical pathway.
Poppelaars, Felix, Thurman, Joshua M.
core +1 more source
Floridoside Extracted from the Red Alga Mastocarpus stellatus Is a Potent Activator of the Classical Complement Pathway [PDF]
, 2008 Many biological properties of algae have been found to have useful applications in human health, particularly in the fields of oncology and immunology.
Berthou, Christian +6 more
core +4 more sources
CRP Enhances the Innate Killing Mechanisms Phagocytosis and ROS Formation in a Conformation and Complement-Dependent Manner [PDF]
, 2021 Phagocytosis and the formation of reactive oxygen species (ROS) in phagocytic leukocytes are an effective killing mechanism of the innate host defense. These cellular processes of innate immunity function in a complex interplay with humoral factors.
Balázs Bogner +11 more
core +3 more sources