Legionella pneumophila lipopolysaccharide activates the classical complement pathway [PDF]
Infection and Immunity, 1992 Legionella pneumophila is a gram-negative bacterium capable of entering and growing in alveolar macrophages and monocytes. Complement and complement receptors are important in the uptake of L. pneumophila by human mononuclear phagocytes. The surface molecules of L. pneumophila that activate the complement system are unknown.
C S, Mintz +3 more
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Frontiers in Immunology, 2018 The complement system is a tightly regulated network of proteins involved in defense against pathogens, inflammatory processes, and coordination of the innate and adaptive immune responses.
Cecilie E. Hertz +6 more
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Continual Low-Level Activation of the Classical Complement Pathway [PDF]
The Journal of Experimental Medicine, 2001 There is evidence that the classical complement pathway may be activated via a “C1-tickover” mechanism, analogous to the C3-tickover of the alternative pathway. We have quantitated and characterized this pathway of complement activation. Analysis of freshly collected mouse and human plasma revealed that spontaneous C3 activation rapidly occurred with ...
Manderson, A +4 more
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Frontiers in Immunology, 2015 The complement system is a major constituent of the innate immune system. It not only bridges innate and adaptive arms of the immune system but also links the immune system with the coagulation system.
Hany Ibrahim Kenawy +2 more
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The classical pathway triggers pathogenic complement activation in membranous nephropathy
Nature Communications, 2023 It is generally thought that complement activation in human membranous nephropathy (MN) occurs predominantly via the lectin or alternative pathway. Here, the authors show that the classical pathway is the dominant form of complement activation in MN and ...
Larissa Seifert +23 more
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MafB is a critical regulator of complement component C1q [PDF]
, 2017 The transcription factor MafB is expressed by monocytes and macrophages. Efferocytosis (apoptotic cell uptake) by macrophages is important for inhibiting the development of autoimmune diseases, and is greatly reduced in Mafb-deficient macrophages.
Andrea Christina-Sylvia +24 more
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Editorial: State-of-the-art research on C1q and the classical complement pathway [PDF]
, 2016 International ...
Duncan, Ghai, Hair, Harmat, Kishore
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The role of salivary and intestinal complement system inhibitors in the midgut protection of triatomines and mosquitoes. [PDF]
PLoS ONE, 2009 Saliva of haematophagous arthropods contain biomolecules involved directly or indirectly with the haematophagy process, and among them are encountered some complement system inhibitors.
Veruska Cavalcanti Barros +7 more
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C1q-targeted inhibition of the classical complement pathway prevents injury in a novel mouse model of acute motor axonal neuropathy [PDF]
, 2016 Introduction Guillain-Barré syndrome (GBS) is an autoimmune disease that results in acute paralysis through inflammatory attack on peripheral nerves, and currently has limited, non-specific treatment options.
Barrie, Jennifer A. +8 more
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Ischemia and reperfusion injury in kidney transplantation : relevant mechanisms in injury and repair [PDF]
, 2020 Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation.
Berger, Stefan P. +7 more
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