Complement Receptors and Their Role in Leukocyte Recruitment and Phagocytosis. [PDF]
Front Cell Dev Biol, 2021 The complement system is deeply embedded in our physiology and immunity. Complement activation generates a multitude of molecules that converge simultaneously on the opsonization of a target for phagocytosis and activation of the immune system via ...
Vandendriessche S +3 more
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Structural Immunology of Complement Receptors 3 and 4. [PDF]
Front Immunol, 2018 Complement receptors (CR) 3 and 4 belong to the family of beta-2 (CD18) integrins. CR3 and CR4 are often co-expressed in the myeloid subsets of leukocytes, but they are also found in NK cells and activated T and B lymphocytes.
Vorup-Jensen T, Jensen RK.
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The Complement Receptors C3aR and C5aR Are a New Class of Immune Checkpoint Receptor in Cancer Immunotherapy. [PDF]
Front Immunol, 2019 Cancer immunotherapy has made remarkable clinical advances in recent years. Antibodies targeting the immune checkpoint receptors PD-1 and CTLA-4 and adoptive cell therapy (ACT) based on ex vivo expanded peripheral CTLs, tumor infiltrating lymphocytes ...
Wang Y, Zhang H, He YW.
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An Immunoregulatory Role for Complement Receptors in Murine Models of Breast Cancer. [PDF]
Antibodies (Basel), 2021 The complement system has demonstrated roles in regulating tumor growth, although these may differ between tumor types. The current study used two murine breast cancer models (EMT6 and 4T1) to investigate whether pharmacological targeting of receptors ...
Akhir FNM +11 more
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Phagocytosis of leprosy bacilli is mediated by complement receptors CR1 and CR3 on human monocytes and complement component C3 in serum. [PDF]
Journal of Clinical Investigation, 1990 Mycobacterium leprae, an obligate intracellular pathogen, invades and multiplies within host mononuclear phagocytes. To understand M. leprae invasion better, we have investigated the role of phagocyte receptors and bacterium-bound ligands in phagocytosis
Larry S. Schlesinger, Marcus A. Horwitz
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Role of Complement Receptors (CRs) on DCs in Anti-HIV-1 Immunity. [PDF]
Front Immunol, 2020 Upon entry of human immunodeficiency virus 1 (HIV-1) into the host, innate immune mechanisms are acting as a first line of defense, that considerably also modify adaptive immunity by the provision of specific signals. Innate and adaptive immune responses
Posch W +3 more
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Mass cytometric analysis of the immune cell landscape after traumatic brain injury elucidates the role of complement and complement receptors in neurologic outcomes. [PDF]
Acta Neuropathol Commun, 2023 Following traumatic brain injury (TBI), a neuroinflammatory response can persist for years and contribute to the development of chronic neurological manifestations.
Toutonji A +5 more
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Relative Impact of Complement Receptors CD21/35 (Cr2/1) on Scrapie Pathogenesis in Mice. [PDF]
mSphere, 2017 Complement receptors 1 and 2 (CR1/2 or CD35/CD21) recognize complement-opsonized antigens to initiate innate and adaptive immunity, respectively. CD35 stimulates phagocytosis on macrophages and antigen presentation on follicular dendritic cells (FDCs ...
Kane SJ +8 more
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RIAM-VASP Module Relays Integrin Complement Receptors in Outside-In Signaling Driving Particle Engulfment. [PDF]
Cells, 2020 The phagocytic integrins and complement receptors αMβ2/CR3 and αXβ2/CR4 are classically associated with the phagocytosis of iC3b-opsonized particles.
Torres-Gomez A +8 more
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Complement Receptors in Myeloid Cell Adhesion and Phagocytosis. [PDF]
Microbiol Spectr, 2016 Dustin ML.
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