Complement Receptors and Their Role in Leukocyte Recruitment and Phagocytosis [PDF]
Frontiers in Cell and Developmental Biology, 2021 The complement system is deeply embedded in our physiology and immunity. Complement activation generates a multitude of molecules that converge simultaneously on the opsonization of a target for phagocytosis and activation of the immune system via ...
Sofie Vandendriessche +3 more
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Structural biology of complement receptors [PDF]
Frontiers in Immunology, 2023 The complement system plays crucial roles in a wide breadth of immune and inflammatory processes and is frequently cited as an etiological or aggravating factor in many human diseases, from asthma to cancer.
Jorge Santos-López +4 more
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Structural Immunology of Complement Receptors 3 and 4 [PDF]
Frontiers in Immunology, 2018 Complement receptors (CR) 3 and 4 belong to the family of beta-2 (CD18) integrins. CR3 and CR4 are often co-expressed in the myeloid subsets of leukocytes, but they are also found in NK cells and activated T and B lymphocytes.
Thomas Vorup-Jensen +2 more
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The Complement Receptors C3aR and C5aR Are a New Class of Immune Checkpoint Receptor in Cancer Immunotherapy [PDF]
Frontiers in Immunology, 2019 Cancer immunotherapy has made remarkable clinical advances in recent years. Antibodies targeting the immune checkpoint receptors PD-1 and CTLA-4 and adoptive cell therapy (ACT) based on ex vivo expanded peripheral CTLs, tumor infiltrating lymphocytes ...
Yu Wang, Hui Zhang, You-Wen He
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Dysfunction of complement receptors CR3 (CD11b/18) and CR4 (CD11c/18) in pre-eclampsia: a genetic and functional study. [PDF]
BJOG, 2021 To study genetic variants and their function within genes coding for complement receptors in pre‐eclampsia.
Lokki AI +16 more
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An Immunoregulatory Role for Complement Receptors in Murine Models of Breast Cancer [PDF]
Antibodies, 2021 The complement system has demonstrated roles in regulating tumor growth, although these may differ between tumor types. The current study used two murine breast cancer models (EMT6 and 4T1) to investigate whether pharmacological targeting of receptors ...
Fazrena Nadia Md Akhir +11 more
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Mass cytometric analysis of the immune cell landscape after traumatic brain injury elucidates the role of complement and complement receptors in neurologic outcomes [PDF]
Acta Neuropathologica Communications, 2023 Following traumatic brain injury (TBI), a neuroinflammatory response can persist for years and contribute to the development of chronic neurological manifestations.
Amer Toutonji +5 more
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Role of Complement Receptors (CRs) on DCs in Anti-HIV-1 Immunity [PDF]
Frontiers in Immunology, 2020 Upon entry of human immunodeficiency virus 1 (HIV-1) into the host, innate immune mechanisms are acting as a first line of defense, that considerably also modify adaptive immunity by the provision of specific signals. Innate and adaptive immune responses
Wilfried Posch +4 more
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Blood Transcriptome Analysis of Septic Patients Reveals a Long Non-Coding Alu-RNA in the Complement C5a Receptor 1 Gene [PDF]
Non-Coding RNA, 2022 Many severe inflammation conditions are complement-dependent with the complement component C5a-C5aR1 axis as an important driver. At the RNA level, the blood transcriptome undergoes programmed expression of coding and long non-coding RNAs to combat ...
Åse Emblem +7 more
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Relative Impact of Complement Receptors CD21/35 (Cr2/1) on Scrapie Pathogenesis in Mice [PDF]
mSphere, 2017 Complement receptors 1 and 2 (CR1/2 or CD35/CD21) recognize complement-opsonized antigens to initiate innate and adaptive immunity, respectively. CD35 stimulates phagocytosis on macrophages and antigen presentation on follicular dendritic cells (FDCs ...
Sarah J. Kane +8 more
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