Results 11 to 20 of about 341,873 (298)

Biomimetic carbon nanopolymers ANM-NPs act on mannose receptors and complement receptors to promote tumor antigen presentation [PDF]

Journal for ImmunoTherapy of Cancer
Background Enhancing immunogenicity and antigen-presentation efficiency is critical for tumor vaccine development. While yeast-surface glycoprotein side chains can improve antigen presentation, their ability to deliver tumor antigens remains limited ...
Lei Zhang, Tao Sun, Heng Zhang, Yujie Sun, Yi-Nan Li, Huijuan Liu, Zhuangzhuang Feng, Xinxiu Shi, Zhiyang Li, Minming Lou, Bijia Cui, Mengzhan Chen   +11 more
doaj   +2 more sources

The Complement Receptors C3aR and C5aR Are a New Class of Immune Checkpoint Receptor in Cancer Immunotherapy [PDF]

Frontiers in Immunology, 2019
Cancer immunotherapy has made remarkable clinical advances in recent years. Antibodies targeting the immune checkpoint receptors PD-1 and CTLA-4 and adoptive cell therapy (ACT) based on ex vivo expanded peripheral CTLs, tumor infiltrating lymphocytes ...
Yu Wang, Hui Zhang, You-Wen He
doaj   +2 more sources

Blood Transcriptome Analysis of Septic Patients Reveals a Long Non-Coding Alu-RNA in the Complement C5a Receptor 1 Gene

Non-Coding RNA, 2022
Many severe inflammation conditions are complement-dependent with the complement component C5a-C5aR1 axis as an important driver. At the RNA level, the blood transcriptome undergoes programmed expression of coding and long non-coding RNAs to combat ...
Åse Emblem, Erik Knutsen, Tor Erik Jørgensen, Hilde Fure, Steinar Daae Johansen, Ole-Lars Brekke, Tom Eirik Mollnes, Bård Ove Karlsen   +7 more
doaj   +1 more source

Neutrophils Require Activation to Express Functional Cell-Surface Complement Receptor Immunoglobulin

Frontiers in Immunology, 2022
The phagocytosis-promoting complement receptor, Complement Receptor Immunoglobulin (CRIg), is exclusively expressed on macrophages. It has been demonstrated that expression in macrophages could be modulated by inflammatory mediators, including cytokines.
Annabelle G. Small, Annabelle G. Small, Annabelle G. Small, Annabelle G. Small, Khalida Perveen, Khalida Perveen, Trishni Putty, Trishni Putty, Nikita Patel, Nikita Patel, Patrick Quinn, Patrick Quinn, Mihir D. Wechalekar, Charles S. Hii, Charles S. Hii, Alex Quach, Alex Quach, Antonio Ferrante, Antonio Ferrante, Antonio Ferrante   +19 more
doaj   +1 more source

Receptor-Mediated NETosis on Neutrophils

Frontiers in Immunology, 2021
Neutrophil extracellular traps (NETs), a web-like structures containing chromatin, have a significant role in assisting the capture and killing of microorganisms by neutrophils during infection.
Tao Chen, Tao Chen, Tao Chen, Yanhong Li, Yanhong Li, Yanhong Li, Rui Sun, Rui Sun, Rui Sun, Huifang Hu, Huifang Hu, Huifang Hu, Yi Liu, Yi Liu, Yi Liu, Martin Herrmann, Yi Zhao, Yi Zhao, Yi Zhao, Luis E. Muñoz   +19 more
doaj   +1 more source

Helix 8 in chemotactic receptors of the complement system.

PLoS Computational Biology, 2022
Host response to infection involves the activation of the complement system leading to the production of anaphylatoxins C3a and C5a. Complement factor C5a exerts its effect through the activation of C5aR1, chemotactic receptor 1, and triggers the G ...
Szymon Wisniewski, Paulina Dragan, Anna Makal, Dorota Latek   +3 more
doaj   +1 more source

The Role of Complement in the Mechanism of Action of Therapeutic Anti-Cancer mAbs

Antibodies, 2020
Unconjugated anti-cancer IgG1 monoclonal antibodies (mAbs) activate antibody-dependent cellular cytotoxicity (ADCC) by natural killer (NK) cells and antibody-dependent cellular phagocytosis (ADCP) by macrophages, and these activities are thought to be ...
Josée Golay, Ronald P. Taylor
doaj   +1 more source

Amyloid-β1-42 oligomers enhance mGlu5R-dependent synaptic weakening via NMDAR activation and complement C5aR1 signaling

iScience, 2023
Summary: Synaptic weakening and loss are well-correlated with the pathology of Alzheimer’s disease (AD). Oligomeric amyloid beta (oAβ) is considered a major synaptotoxic trigger for AD.
Ai Na Ng, Eric W. Salter, John Georgiou, Zuner A. Bortolotto, Graham L. Collingridge   +4 more
doaj   +1 more source

Ischemia and reperfusion injury in kidney transplantation : relevant mechanisms in injury and repair [PDF]

, 2020
Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation.
Berger, Stefan P., Leuvenink, Henri G. D., Nieuwenhuijs-Moeke, Gertrude J., Pischke, Soren E., Ploeg, Rutger J., Pol, Robert A., Sanders, Jan Stephan F., Struys, Michel   +7 more
core   +2 more sources

Innate and adaptive AAV-mediated immune responses in a mouse model of Duchenne muscular dystrophy

Molecular Therapy: Methods & Clinical Development, 2023
High systemic doses of adeno-associated viruses (AAVs) have been associated with immune-related serious adverse events (SAEs). Although AAV was well tolerated in preclinical models, SAEs were observed in clinical trials, indicating the need for improved ...
Michael R. Emami, Alejandro Espinoza, Courtney S. Young, Feiyang Ma, Philip K. Farahat, Philip L. Felgner, Jeffrey S. Chamberlain, Xiangmin Xu, April D. Pyle, Matteo Pellegrini, S. Armando Villalta, Melissa J. Spencer   +11 more
doaj   +1 more source