Results 21 to 30 of about 197,380 (294)

The Role of Complement in the Mechanism of Action of Therapeutic Anti-Cancer mAbs

Antibodies, 2020
Unconjugated anti-cancer IgG1 monoclonal antibodies (mAbs) activate antibody-dependent cellular cytotoxicity (ADCC) by natural killer (NK) cells and antibody-dependent cellular phagocytosis (ADCP) by macrophages, and these activities are thought to be ...
Josée Golay, Ronald P. Taylor
doaj   +1 more source

Helix 8 in chemotactic receptors of the complement system.

PLoS Computational Biology, 2022
Host response to infection involves the activation of the complement system leading to the production of anaphylatoxins C3a and C5a. Complement factor C5a exerts its effect through the activation of C5aR1, chemotactic receptor 1, and triggers the G ...
Szymon Wisniewski, Paulina Dragan, Anna Makal, Dorota Latek   +3 more
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Amyloid-β1-42 oligomers enhance mGlu5R-dependent synaptic weakening via NMDAR activation and complement C5aR1 signaling

iScience, 2023
Summary: Synaptic weakening and loss are well-correlated with the pathology of Alzheimer’s disease (AD). Oligomeric amyloid beta (oAβ) is considered a major synaptotoxic trigger for AD.
Ai Na Ng, Eric W. Salter, John Georgiou, Zuner A. Bortolotto, Graham L. Collingridge   +4 more
doaj   +1 more source

Innate and adaptive AAV-mediated immune responses in a mouse model of Duchenne muscular dystrophy

Molecular Therapy: Methods & Clinical Development, 2023
High systemic doses of adeno-associated viruses (AAVs) have been associated with immune-related serious adverse events (SAEs). Although AAV was well tolerated in preclinical models, SAEs were observed in clinical trials, indicating the need for improved ...
Michael R. Emami, Alejandro Espinoza, Courtney S. Young, Feiyang Ma, Philip K. Farahat, Philip L. Felgner, Jeffrey S. Chamberlain, Xiangmin Xu, April D. Pyle, Matteo Pellegrini, S. Armando Villalta, Melissa J. Spencer   +11 more
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A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo [PDF]

, 2000
The strongest susceptibility genes for the development of systemic lupus erythematosus (SLE) in humans are null mutants of classical pathway complement proteins. There is a hierarchy of disease susceptibility and severity according to the position of the
H. Terence Cook, Savill, John, Henson, Peter M, Cook, HT, Valerie A. Fadok, Taylor, P.R, Henson, PM, Mark J. Walport, Savill, JS, Walport, MJ, Philip R. Taylor, John S. Savill, Michael C. Carroll, Botto, M, Andrews, Mark, Taylor, PR, Fadok, Valerie A, Anna Carugati, Carroll, Michael C, Walport, Mark J, Carroll, MC, Marina Botto, Carugati, A, Peter M. Henson, Andrews, M, Mark Andrews, Botto, Marina, Fadok, VA, Carugati, Anna, Cook, H. Terence   +29 more
core   +1 more source

The many roles of C1q

eLife, 2020
The ability of a well-known component of the complement cascade to bind to a variety of receptors has implications for signaling biology, spinal cord injury and, possibly, the evolution of the complement system.
Mark Noble, Christoph Pröschel
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Complement System: An Immunotherapy Target in Colorectal Cancer

Frontiers in Immunology, 2022
Colorectal cancer (CRC) is the third most common malignant tumor and the second most fatal cancer worldwide. Several parts of the immune system contribute to fighting cancer including the innate complement system.
Iman M. Talaat, Iman M. Talaat, Iman M. Talaat, Noha Mousaad Elemam, Noha Mousaad Elemam, Maha Saber-Ayad, Maha Saber-Ayad, Maha Saber-Ayad   +7 more
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Properdin Modulates Complement Component Production in Stressed Human Primary Retinal Pigment Epithelium Cells

Antioxidants, 2020
The retinal pigment epithelium (RPE) maintains visual function and preserves structural integrity of the retina. Chronic dysfunction of the RPE is associated with retinal degeneration, including age-related macular degeneration (AMD).
Nicole Schäfer, Hannah N. Wolf, Anne Enzbrenner, Juliane Schikora, Maria Reichenthaler, Volker Enzmann, Diana Pauly   +6 more
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Complement 1q/Tumor Necrosis Factor-Related Proteins (CTRPs): Structure, Receptors and Signaling

Biomedicines, 2023
Adiponectin and the other 15 members of the complement 1q (C1q)/tumor necrosis factor (TNF)-related protein (CTRP) family are secreted proteins composed of an N-terminal variable domain followed by a stalk region and a characteristic C-terminal ...
Constanze Schanbacher, Heike M. Hermanns, Kristina Lorenz, Harald Wajant, Isabell Lang   +4 more
doaj   +1 more source

Complement Plays a Critical Role in Inflammation-Induced Immunoprophylaxis Failure in Mice

Frontiers in Immunology, 2021
Complement impacts innate and adaptive immunity. Using a model in which the human KEL glycoprotein is expressed on murine red blood cells (RBCs), we have shown that polyclonal immunoprophylaxis (KELIg) prevents alloimmunization to transfused RBCs when a ...
Vicente Escamilla-Rivera, Manjula Santhanakrishnan, Jingchun Liu, David R. Gibb, James E. Forsmo, James E. Forsmo, Ellen F. Foxman, Ellen F. Foxman, Stephanie C. Eisenbarth, Stephanie C. Eisenbarth, C. John Luckey, James C. Zimring, Krystalyn E. Hudson, Sean R. Stowell, Sean R. Stowell, Jeanne E. Hendrickson, Jeanne E. Hendrickson   +16 more
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