Innate and adaptive AAV-mediated immune responses in a mouse model of Duchenne muscular dystrophy
Molecular Therapy: Methods & Clinical Development, 2023 High systemic doses of adeno-associated viruses (AAVs) have been associated with immune-related serious adverse events (SAEs). Although AAV was well tolerated in preclinical models, SAEs were observed in clinical trials, indicating the need for improved ...
Michael R. Emami +11 more
doaj +1 more source
Innate immune system activation in zebrafish and cellular models of Diamond Blackfan Anemia. [PDF]
, 2018 Deficiency of ribosomal proteins (RPs) leads to Diamond Blackfan Anemia (DBA) associated with anemia, congenital defects, and cancer. While p53 activation is responsible for many features of DBA, the role of immune system is less defined.
Bibikova, Elena +5 more
core +2 more sources
Liver Transplantation to Provide Low-Density-Lipoprotein Receptors and Lower Plasma Cholesterol in a Child with Homozygous Familial Hypercholesterolemia [PDF]
, 1984 A six-year-old girl with severe hypercholesterolemia and atherosclerosis had two defective genes at the low-density-lipoprotein (LDL) receptor locus, as determined by biochemical studies of cultured fibroblasts.
Cummings +9 more
core +1 more source
eLife, 2020 The ability of a well-known component of the complement cascade to bind to a variety of receptors has implications for signaling biology, spinal cord injury and, possibly, the evolution of the complement system.
Mark Noble, Christoph Pröschel
doaj +1 more source
Complement System: An Immunotherapy Target in Colorectal Cancer
Frontiers in Immunology, 2022 Colorectal cancer (CRC) is the third most common malignant tumor and the second most fatal cancer worldwide. Several parts of the immune system contribute to fighting cancer including the innate complement system.
Iman M. Talaat +7 more
doaj +1 more source
Human platelets and their capacity of binding viruses: Meaning and challenges? [PDF]
, 2015 Blood platelets are first aimed at ensuring primary hemostasis. Beyond this role, they have been acknowledged as having functions in the maintenance of the vascular arborescence and, more recently, as being also innate immune cells, devoted notably to ...
Chabert, Adrien +6 more
core +2 more sources
Nanoparticles-cell association predicted by protein corona fingerprints [PDF]
, 2016 In a physiological environment (e.g., blood and interstitial fluids) nanoparticles (NPs) will bind proteins shaping a "protein corona" layer. The long-lived protein layer tightly bound to the NP surface is referred to as the hard corona (HC) and encodes ...
Caracciolo, Giulio +6 more
core +3 more sources
Antioxidants, 2020 The retinal pigment epithelium (RPE) maintains visual function and preserves structural integrity of the retina. Chronic dysfunction of the RPE is associated with retinal degeneration, including age-related macular degeneration (AMD).
Nicole Schäfer +6 more
doaj +1 more source
Complement Plays a Critical Role in Inflammation-Induced Immunoprophylaxis Failure in Mice
Frontiers in Immunology, 2021 Complement impacts innate and adaptive immunity. Using a model in which the human KEL glycoprotein is expressed on murine red blood cells (RBCs), we have shown that polyclonal immunoprophylaxis (KELIg) prevents alloimmunization to transfused RBCs when a ...
Vicente Escamilla-Rivera +16 more
doaj +1 more source
CR3 is the dominant phagocytotic complement receptor on human dendritic cells. [PDF]
, 2013 Dendritic cells (DCs) play a decisive role in immunity; they interact with various pathogens via several pattern recognition and different opsonophagocytotic receptors, including Fc- and complement-receptors. beta2-integrins, including complement
Abram +56 more
core +1 more source