Results 21 to 30 of about 1,111,236 (286)

Complement Receptors in Myeloid Cell Adhesion and Phagocytosis. [PDF]

Microbiol Spectr, 2016
Myeloid cells make extensive use of the complement system in the context of recruitment, phagocytosis, and other effector functions. There are several types of complement receptors on myeloid cells, including G protein-coupled receptors for localizing ...
Dustin ML.
europepmc   +2 more sources

Helix 8 in chemotactic receptors of the complement system.

PLoS Computational Biology, 2022
Host response to infection involves the activation of the complement system leading to the production of anaphylatoxins C3a and C5a. Complement factor C5a exerts its effect through the activation of C5aR1, chemotactic receptor 1, and triggers the G ...
Szymon Wisniewski, Paulina Dragan, Anna Makal, Dorota Latek   +3 more
doaj   +1 more source

Amyloid-β1-42 oligomers enhance mGlu5R-dependent synaptic weakening via NMDAR activation and complement C5aR1 signaling

iScience, 2023
Summary: Synaptic weakening and loss are well-correlated with the pathology of Alzheimer’s disease (AD). Oligomeric amyloid beta (oAβ) is considered a major synaptotoxic trigger for AD.
Ai Na Ng, Eric W. Salter, John Georgiou, Zuner A. Bortolotto, Graham L. Collingridge   +4 more
doaj   +1 more source

The Role of Complement in the Mechanism of Action of Therapeutic Anti-Cancer mAbs

Antibodies, 2020
Unconjugated anti-cancer IgG1 monoclonal antibodies (mAbs) activate antibody-dependent cellular cytotoxicity (ADCC) by natural killer (NK) cells and antibody-dependent cellular phagocytosis (ADCP) by macrophages, and these activities are thought to be ...
Josée Golay, Ronald P. Taylor
doaj   +1 more source

Complement peptide receptors in GtoPdb v.2021.3 [PDF]

, 2021
Complement peptide receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on Complement peptide receptors [107]) are activated by the endogenous ~75 amino-acid anaphylatoxin polypeptides C3a and C5a, generated upon stimulation of the complement ...
Lee, John D., Monk, Peter, Mitolo, Vincenzo, Woodruff, Trent M., Coulthard, Liam, Cianciulli, Antonia, Panaro, Maria A., Li, Xaria X., Hawksworth, Owen   +8 more
core   +1 more source

Innate and adaptive AAV-mediated immune responses in a mouse model of Duchenne muscular dystrophy

Molecular Therapy: Methods & Clinical Development, 2023
High systemic doses of adeno-associated viruses (AAVs) have been associated with immune-related serious adverse events (SAEs). Although AAV was well tolerated in preclinical models, SAEs were observed in clinical trials, indicating the need for improved ...
Michael R. Emami, Alejandro Espinoza, Courtney S. Young, Feiyang Ma, Philip K. Farahat, Philip L. Felgner, Jeffrey S. Chamberlain, Xiangmin Xu, April D. Pyle, Matteo Pellegrini, S. Armando Villalta, Melissa J. Spencer   +11 more
doaj   +1 more source

A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo [PDF]

, 2000
The strongest susceptibility genes for the development of systemic lupus erythematosus (SLE) in humans are null mutants of classical pathway complement proteins. There is a hierarchy of disease susceptibility and severity according to the position of the
H. Terence Cook, Savill, John, Henson, Peter M, Cook, HT, Valerie A. Fadok, Taylor, P.R, Henson, PM, Mark J. Walport, Savill, JS, Walport, MJ, Philip R. Taylor, John S. Savill, Michael C. Carroll, Botto, M, Andrews, Mark, Taylor, PR, Fadok, Valerie A, Anna Carugati, Carroll, Michael C, Walport, Mark J, Carroll, MC, Marina Botto, Carugati, A, Peter M. Henson, Andrews, M, Mark Andrews, Botto, Marina, Fadok, VA, Carugati, Anna, Cook, H. Terence   +29 more
core   +1 more source

Backbone dynamics of complement control protein (CCP) modules reveals mobility in binding surfaces [PDF]

, 2004
The regulators of complement activation (RCA) are critical to health and disease because their role is to ensure that a complement-mediated immune response to infection is proportionate and targeted.
Krystyna Bromek, Uhrin, D, O'Leary, JM, Xuefeng Wang, Stanislava Uhrinova, Joanne M. O'Leary, Black, GM, Wang, XF, Malgorzata Krych, John P. Atkinson, Uhrinova, S, Dusan Uhrin, Atkinson, JP, Gordon M. Black, Krych, M, Schmitz, C, Paul N. Barlow, Bromek, K, Barlow, PN, Christian Schmitz   +19 more
core   +1 more source

The many roles of C1q

eLife, 2020
The ability of a well-known component of the complement cascade to bind to a variety of receptors has implications for signaling biology, spinal cord injury and, possibly, the evolution of the complement system.
Mark Noble, Christoph Pröschel
doaj   +1 more source

Complement peptide receptors in GtoPdb v.2023.1 [PDF]

, 2023
Complement peptide receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on Complement peptide receptors [113]) are activated by the endogenous ~75 amino-acid anaphylatoxin polypeptides C3a and C5a, generated upon stimulation of the complement ...
John D. Lee, Lee, John D., Xaria X. Li, Antonia Cianciulli, Hawksworth, Owen, Owen Hawksworth, Monk, Peter, Liam Coulthard, Peter Monk, Vincenzo Mitolo, Mitolo, Vincenzo, Maria A. Panaro, Woodruff, Trent M., Coulthard, Liam, Trent M. Woodruff, Cianciulli, Antonia, Panaro, Maria A., Li, Xaria X.   +17 more
core   +1 more source