Results 11 to 20 of about 197,380 (294)
Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors [PDF]
Cell, 2023 Manisankar Ganguly, Sudha Mishra
exaly +2 more sources
The Complement Receptors C3aR and C5aR Are a New Class of Immune Checkpoint Receptor in Cancer Immunotherapy [PDF]
Frontiers in Immunology, 2019 Cancer immunotherapy has made remarkable clinical advances in recent years. Antibodies targeting the immune checkpoint receptors PD-1 and CTLA-4 and adoptive cell therapy (ACT) based on ex vivo expanded peripheral CTLs, tumor infiltrating lymphocytes ...
Yu Wang, Hui Zhang, You-Wen He
doaj +2 more sources
Complement Proteins as Soluble Pattern Recognition Receptors for Pathogenic Viruses
Viruses, 2021 The complement system represents a crucial part of innate immunity. It contains a diverse range of soluble activators, membrane-bound receptors, and regulators.
Valarmathy Murugaiah +5 more
doaj +2 more sources
A new perspective on the pathophysiology of kidney diseases: the intracellular complement system- “complosome” [PDF]
Frontiers in NephrologyThe complement cascade is a vital component of the innate immune system. It consists of around 50 proteins, including circulating complement proteins and membrane-bound receptors. It operates through three main activation pathways: classical, lectin, and
Emre Leventoğlu, Sevcan A. Bakkaloğlu
doaj +2 more sources
Complement Receptors in Myeloid Cell Adhesion and Phagocytosis. [PDF]
Microbiol Spectr, 2016 Myeloid cells make extensive use of the complement system in the context of recruitment, phagocytosis, and other effector functions. There are several types of complement receptors on myeloid cells, including G protein-coupled receptors for localizing ...
Dustin ML.
europepmc +2 more sources
The Role of Complement in Cancer Immunotherapy [PDF]
, 2022 The dual role of complement in both cancer development and treatment has been investigated extensively and is characterized by a substantial literature that documents the conditions in which complement can either enhance tumor growth or promote the ...
core +1 more source
Non-Coding RNA, 2022 Many severe inflammation conditions are complement-dependent with the complement component C5a-C5aR1 axis as an important driver. At the RNA level, the blood transcriptome undergoes programmed expression of coding and long non-coding RNAs to combat ...
Åse Emblem +7 more
doaj +1 more source
Neutrophils Require Activation to Express Functional Cell-Surface Complement Receptor Immunoglobulin
Frontiers in Immunology, 2022 The phagocytosis-promoting complement receptor, Complement Receptor Immunoglobulin (CRIg), is exclusively expressed on macrophages. It has been demonstrated that expression in macrophages could be modulated by inflammatory mediators, including cytokines.
Annabelle G. Small +19 more
doaj +1 more source
RECEPTORS FOR COMPLEMENT ON LEUKOCYTES [PDF]
The Journal of Experimental Medicine, 1968 Sheep red blood cells sensitized by 7S, but not by 19S rabbit anti-Forssman antibodies, adhere and form rosettes on mouse macrophages and on a few monocytes and polymorphonuclear cells (PMN). When, however, C' factors from mouse serum are added to the antigen-19S antibody complex (EAC'), rosettes are formed on most mouse peritoneal macrophages and PMN ...
W H, Lay, V, Nussenzweig
openaire +2 more sources
Receptor-Mediated NETosis on Neutrophils
Frontiers in Immunology, 2021 Neutrophil extracellular traps (NETs), a web-like structures containing chromatin, have a significant role in assisting the capture and killing of microorganisms by neutrophils during infection.
Tao Chen +19 more
doaj +1 more source