Results 21 to 30 of about 341,873 (298)

CR3 is the dominant phagocytotic complement receptor on human dendritic cells. [PDF]

, 2013
Dendritic cells (DCs) play a decisive role in immunity; they interact with various pathogens via several pattern recognition and different opsonophagocytotic receptors, including Fc- and complement-receptors. beta2-integrins, including complement
Abram, Anna Erdei, Bajtay, Bajtay, Behrens, Berton, Birdsall, Bretscher, Bunting, Capron, Carroll, Carroll, Domonkos Pap, Dupuy, Ehirchiou, Erdei, Erdei, Fabry, Gelderman, Gelderman, Georgakopoulos, Gergely, Graham, Gresham, Kacani, Katalin Kristóf, Katalin Paréj, Kemper, Kerekes, Li, Liu, MacPherson, Maison, Morelli, Nauta, Nauta, Noémi Sándor, Oliva, Papp, Pickl, Prechtel, Rosen, Ross, Sandor, Schmidt, Skoberne, Sohn, Turner, Török, van Spriel, van Spriel, Varga, Veldhoen, Verbovetski, Vignali, Wagner, Zsuzsa Bajtay   +56 more
core   +1 more source

Liver Transplantation to Provide Low-Density-Lipoprotein Receptors and Lower Plasma Cholesterol in a Child with Homozygous Familial Hypercholesterolemia [PDF]

, 1984
A six-year-old girl with severe hypercholesterolemia and atherosclerosis had two defective genes at the low-density-lipoprotein (LDL) receptor locus, as determined by biochemical studies of cultured fibroblasts.
Cummings, David W. Bilheimer, Goldstein, Joseph L. Goldstein, Michael S. Brown, Pittman, Schneider, Schneider, Scott M. Grundy, Thomas E. Starzl   +9 more
core   +1 more source

The many roles of C1q

eLife, 2020
The ability of a well-known component of the complement cascade to bind to a variety of receptors has implications for signaling biology, spinal cord injury and, possibly, the evolution of the complement system.
Mark Noble, Christoph Pröschel
doaj   +1 more source

Complement System: An Immunotherapy Target in Colorectal Cancer

Frontiers in Immunology, 2022
Colorectal cancer (CRC) is the third most common malignant tumor and the second most fatal cancer worldwide. Several parts of the immune system contribute to fighting cancer including the innate complement system.
Iman M. Talaat, Iman M. Talaat, Iman M. Talaat, Noha Mousaad Elemam, Noha Mousaad Elemam, Maha Saber-Ayad, Maha Saber-Ayad, Maha Saber-Ayad   +7 more
doaj   +1 more source

Properdin Modulates Complement Component Production in Stressed Human Primary Retinal Pigment Epithelium Cells

Antioxidants, 2020
The retinal pigment epithelium (RPE) maintains visual function and preserves structural integrity of the retina. Chronic dysfunction of the RPE is associated with retinal degeneration, including age-related macular degeneration (AMD).
Nicole Schäfer, Hannah N. Wolf, Anne Enzbrenner, Juliane Schikora, Maria Reichenthaler, Volker Enzmann, Diana Pauly   +6 more
doaj   +1 more source

Complement Plays a Critical Role in Inflammation-Induced Immunoprophylaxis Failure in Mice

Frontiers in Immunology, 2021
Complement impacts innate and adaptive immunity. Using a model in which the human KEL glycoprotein is expressed on murine red blood cells (RBCs), we have shown that polyclonal immunoprophylaxis (KELIg) prevents alloimmunization to transfused RBCs when a ...
Vicente Escamilla-Rivera, Manjula Santhanakrishnan, Jingchun Liu, David R. Gibb, James E. Forsmo, James E. Forsmo, Ellen F. Foxman, Ellen F. Foxman, Stephanie C. Eisenbarth, Stephanie C. Eisenbarth, C. John Luckey, James C. Zimring, Krystalyn E. Hudson, Sean R. Stowell, Sean R. Stowell, Jeanne E. Hendrickson, Jeanne E. Hendrickson   +16 more
doaj   +1 more source

CR2 Complement Receptor

Journal of Investigative Dermatology, 1990
CR2, a membrane glycoprotein, is one of a number of cell-surface proteins which bind activation and processing fragments of the complement system. CR2, which is found on normal B lymphocytes, follicular dendritic cells in lymphoid organs, and epithelial cells, interacts preferentially with C3dg, the terminal activation/processing fragment of the third ...
Cooper, Neil R, Bradt, Bonnie M, Rhim, Johng S, Nemerow, Glen R   +3 more
openaire   +2 more sources

Innate immune system activation in zebrafish and cellular models of Diamond Blackfan Anemia. [PDF]

, 2018
Deficiency of ribosomal proteins (RPs) leads to Diamond Blackfan Anemia (DBA) associated with anemia, congenital defects, and cancer. While p53 activation is responsible for many features of DBA, the role of immune system is less defined.
Bibikova, Elena, Danilova, Nadia, Lin, Shuo, Sakamoto, Kathleen M, Wilkes, Mark, Youn, Min-Young   +5 more
core   +2 more sources

Complement 1q/Tumor Necrosis Factor-Related Proteins (CTRPs): Structure, Receptors and Signaling

Biomedicines, 2023
Adiponectin and the other 15 members of the complement 1q (C1q)/tumor necrosis factor (TNF)-related protein (CTRP) family are secreted proteins composed of an N-terminal variable domain followed by a stalk region and a characteristic C-terminal ...
Constanze Schanbacher, Heike M. Hermanns, Kristina Lorenz, Harald Wajant, Isabell Lang   +4 more
doaj   +1 more source

Menopause leads to elevated expression of macrophage-associated genes in the aging frontal cortex: rat and human studies identify strikingly similar changes. [PDF]

, 2012
BACKGROUND The intricate interactions between the immune, endocrine and central nervous systems shape the innate immune response of the brain. We have previously shown that estradiol suppresses expression of immune genes in the frontal cortex of ...
Carl Cotman, Erik Hrabovszky, Imre Kalló, István Likó, Miklós Sárvári, Nicole Berchtold, Norbert Solymosi, Sárvári, Miklós, Zsolt Liposits   +8 more
core   +2 more sources