Results 221 to 230 of about 1,176 (261)
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Complement Regulatory Proteins and Autoimmunity
2001To discriminate self from non-self is an essential issue in the immune system. Autologous cells are protected against complement-mediated cell injury by the self-recognition mechanism using complement regulatory proteins composed of complement receptor type 1 (CR1, CD35), membrane cofactor protein (MCP, CD46), decay accelerating factor (DAF, CD55) and ...
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Complement factor H and related proteins: an expanding family of complement-regulatory proteins?
Immunology Today, 1994Recently, several factor-H-related molecules have been identified in humans and mice, initiating new interest in this group of serum proteins. Although no complement-regulatory activity has been demonstrated yet for the human factor-H-related proteins, the immunological and structural similarities to factor H suggest overlapping functions.
Peter F. Zipfel, Christine Skerka
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C4b-Binding protein, a regulatory protein of complement
Immunologic Research, 1991Despite the wealth of structural and functional information on C4BP, it is clear that several aspects of C4BP biology and regulation under normal conditions and in the acute-phase response remain unresolved. Studies to identify which interleukin and cytokines regulate C4BP expression (both α-and β-chains) are underway in our laboratory.
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Structure-Function Relationships of the Complement Regulatory Protein, CD59
Blood Cells, Molecules, and Diseases, 1996CD59 (membrane inhibitor of reactive lysis, protectin) is a membrane protein whose functions include the inhibition of the insertion of the ninth component of complement into the target membrane. It belongs to a superfamily of proteins including Ly-6, elapid snake venom toxins, and urokinase receptor (UPAR); the members of the superfamily have a ...
John G. Petranka +6 more
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The expression of complement regulatory proteins by adult human oligodendrocytes
Journal of Neuroimmunology, 1998In multiple sclerosis, infiltrating T lymphocytes and perivascular microglia may initiate demyelinating lesions, but a role for antibody and complement in the ensuing inflammatory damage to myelin and oligodendrocytes is likely. In most tissues, ubiquitously expressed complement regulatory proteins prevent autologous destruction, protecting host cells ...
N.J. Scolding +2 more
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Decreased MRNA expression of complement regulatory proteins in chorioamnionitis [PDF]
American Journal of Obstetrics and Gynecology, 2006 IN CHORIOAMNIONITIS KARINA RICHANI, ELEAZAR SOTO, ROBERTO ROMERO, YU MI HAN, BETH PINELES, YEON MEE KIM, ENOLA CUSHENBERRY, BO HYUN YOON, JUAN P. KUSANOVIC, JIMMY ESPINOZA, CHONG JAI KIM, Wayne State University School of Medicine, Department of Obstetrics and Gynecology, Detroit, Michigan, Perinatology Research Branch, NICHD, NIH, DHHS, Detroit ...
Richani, Karina +10 more
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Expression of complement regulatory proteins in the developing human kidney
Pediatric Nephrology, 2000Complement homologous restriction factor CD59 and complement receptor CD35 are typically involved in the regulation of the host defense system. Recent observations in the human fetal kidney suggest a further role for complement cell surface regulators CD35 and CD59 in kidney development and maturation.
A. Mok +2 more
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Effect of hybrid complement regulatory proteins on xenogeneic cells
Biochemical and Biophysical Research Communications, 2003To suppress C3 fragment deposition in the classical pathway complement activation on xenogeneic membranes, decay accelerating factor (DAF) was the most effective molecule among the complement regulatory proteins (CRPs) used in the present study. C3 fragment deposition was closely related to subsequent xenogeneic cell lysis.
Daisuke Fukuta +6 more
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Expression of complement regulatory proteins in diffuse proliferative glomerulonephritis
Lupus, 2000This study assessed the expression of complement receptor 1 (CR1), decay accelerating factor (DAF) and membrane inhibitor of reactive lysis (CD59) on the erythrocytes and glomerulus of diffuse proliferative glomerulonephritis (DPGN) of systemic lupus erythematosus (SLE) patients using flow cytometry and immunofluorescence techniques to elucidate their
L. M. Srivastava +4 more
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The Journal of Immunology, 1993
Abstract The susceptibility of trophoblast to cytolysis by human complement was investigated using cells purified to over 90% from first trimester placentae. Two assay systems were employed to measure the killing of trophoblasts, an antibody-dependent complement-mediated cytolysis and the reactive lysis.
TEDESCO F. +5 more
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Abstract The susceptibility of trophoblast to cytolysis by human complement was investigated using cells purified to over 90% from first trimester placentae. Two assay systems were employed to measure the killing of trophoblasts, an antibody-dependent complement-mediated cytolysis and the reactive lysis.
TEDESCO F. +5 more
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