Results 111 to 120 of about 24,105,917 (378)
Complement System and C4d expression in cases of Membranous nephropathy
Introduction: Membranous nephropathy (MN) is one of the major causes of nephrotic syndrome. The complement system plays a key role in the pathophysiology of MN.
Fabiano Bichuette Custódio+4 more
doaj +1 more source
The complex functioning of the complement system in xenotransplantation
The role of complement in xenotransplantation is well‐known and is a topic that has been reviewed previously. However, our understanding of the immense complexity of its interaction with other constituents of the innate immune response and of the ...
Hongmin Zhou, H. Hara, D. Cooper
semanticscholar +1 more source
Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou+11 more
wiley +1 more source
Targeting the complement system in bacterial meningitis
Morbidity and mortality in bacterial meningitis are driven by an uncontrolled host inflammatory response. Koelman et al. evaluate the detrimental role of the complement system in spurring this inflammation, and conclude that anaphylatoxin C5a is a ...
D. Koelman, M. Brouwer, D. van de Beek
semanticscholar +1 more source
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin+14 more
wiley +1 more source
Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park+6 more
wiley +1 more source
COMPLEMENT SYSTEM AS A MARKER OF IMMUNE DYSFUNCTION IN CHILDREN AUTISM SPECTRUM DISORDERS
It is known that functional activity of complement system depends not only on balance and concentration of components participating in formation of the system end products, but also on levels of inhibitory activities.
E. G. Cheremnykh+6 more
doaj +1 more source
On the cohomology of discriminantal arrangements and Orlik-Solomon algebras
We relate the cohomology of the Orlik-Solomon algebra of a discriminantal arrangement to the local system cohomology of the complement. The Orlik-Solomon algebra of such an arrangement (viewed as a complex) is shown to be a linear approximation of a ...
Cohen, Daniel C.
core +2 more sources
Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak+14 more
wiley +1 more source
The alternative pathway (AP) of complement is constantly active in plasma and can easily be activated on self surfaces and trigger local inflammation. Host cells are protected from AP attack by Factor H (FH), the main AP regulator in plasma.
Eija Nissilä+15 more
doaj +1 more source