Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren +16 more
wiley +1 more source
Experiments with the Cyprus strain of blue-tongue virus: multiplication in the central nervous system of mice and complement fixation [PDF]
, 1954 M. Van Den Ende +2 more
openalex +1 more source
Complement system and alcoholic liver disease [PDF]
, 2008 Alcoholic liver disease (ALD) is a well recognized and growing health problem worldwide. ALD advances from fatty liver to inflammation, necrosis, fibrosis and cirrhosis.
Bykov, Igor
core
Molecular Oncology, EarlyView.Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop +10 more
wiley +1 more source
Renal FailureObjective The aim of this study was to investigate the potential importance of complement system activation, with particular emphasis on the complement alternative pathway (AP), in the pathogenesis of hypertensive renal damage.Methods Serum complement C3,
Zhongli Wang +8 more
doaj +1 more source
THE COMPLEMENT FIXATION TEST IN THE DIAGNOSIS OF VIRUS INFECTIONS OF THE CENTRAL NERVOUS SYSTEM [PDF]
, 1941 J. Casals, Ronald Palacios
openalex +1 more source
Weighted BFBT Preconditioner for Stokes Flow Problems with Highly Heterogeneous Viscosity
, 2017 We present a weighted BFBT approximation (w-BFBT) to the inverse Schur complement of a Stokes system with highly heterogeneous viscosity. When used as part of a Schur complement-based Stokes preconditioner, we observe robust fast convergence for Stokes ...
Ghattas, Omar +2 more
core +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Role of complement C3 in diabetic nephropathy
Linchuang shenzangbing zazhi, 2022 As one of the most common microvascular complications of diabetes， diabetic kidney disease （DKD） is one of the major causes of end-stage renal disease. Complement system participates in both innate and adaptive immunities of human body. Three pathways of
Wang Qing-qing +3 more
doaj
INVESTIGATION OF THE SPECIFICITY OF SUBSTANCES IN SOME HUMAN SERA WHICH ARE INHIBITORY IN CERTAIN VIRAL AND RICKETTSIAL COMPLEMENT-FIXING ANTIGEN-ANTIBODY SYSTEMS [PDF]
, 1956 Nathalie J. Schmidt, Harry B. Harding
openalex +1 more source