Results 131 to 140 of about 24,757,633 (403)

Geometric structures on the complement of a toric mirror arrangement [PDF]

arXiv, 2018
We study geometric structures on the complement of a toric mirror arrangement associated with a root system. Inspired by those special hypergeometric functions found by Heckman-Opdam, as well as the work of Couwenberg-Heckman-Looijenga on geometric structures on projective arrangement complements, we consider a family of connections on a total space ...
arxiv  

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

The Complement System Is Critical in Maintaining Retinal Integrity during Aging

Frontiers in Aging Neuroscience, 2018
The complement system is a key component of innate immunity comprised of soluble components that form a proteolytic cascade leading to the generation of effector molecules involved in cellular clearance.
Ryo Mukai, Y. Okunuki, D. Husain, Clifford B. Kim, John D Lambris, K. Connor   +5 more
semanticscholar   +1 more source

Complement Factor H and Apolipoprotein E Participate in Regulation of Inflammation in THP-1 Macrophages

Frontiers in Immunology, 2018
The alternative pathway (AP) of complement is constantly active in plasma and can easily be activated on self surfaces and trigger local inflammation. Host cells are protected from AP attack by Factor H (FH), the main AP regulator in plasma.
Eija Nissilä, Pipsa Hakala, Katarzyna Leskinen, Angela Roig, Shahan Syed, Kok P. M. Van Kessel, Jari Metso, Carla J. C. De Haas, Päivi Saavalainen, Seppo Meri, Angeliki Chroni, Jos A. G. Van Strijp, Katariina Öörni, Matti Jauhiainen, T. Sakari Jokiranta, Karita Haapasalo   +15 more
doaj   +1 more source

Non-vanishing of the twisted cohomology on the complement of hypersurfaces [PDF]

arXiv, 2005
Under the generic situation, the cohomology with the coefficients in the local system on complements of hypersurfaces vanishes except in the highest dimension. Our problem is of when the local system cohomology does not vanish. In the case of arrangements of hyperplanes, many examples were founded.
arxiv  

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Complement system and alcoholic liver disease [PDF]

, 2008
Alcoholic liver disease (ALD) is a well recognized and growing health problem worldwide. ALD advances from fatty liver to inflammation, necrosis, fibrosis and cirrhosis.
Bykov, Igor
core  

Eulerian graphs and local complementation [PDF]

arXiv, 2007
We define pure graphs, invertible graphs, and the notion of complementation of bicoloured graphs. The study of pure graphs is motivated by two conjectures about the transition systems of eulerian graphs and by the Cycle Double Cover Conjecture. We show how substitution rules can be used to determine when two complementation words produce the same graph.
arxiv  

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Plant derived bioactive compounds for the treatment of neurodegeneration and neuroimmune disorders associated with the complement system

Exploration of Immunology
The complement system is a key component of the innate immune system that mediates the clearance of pathogens, apoptotic cells, and cellular debris.
Jeyaparthasarathy Narayanaperumal, Ganesh Gopal   +1 more
doaj   +1 more source