Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop +10 more
wiley +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Observations on the Sensitivity of the Haemolytic System in Complement-fixation Tests [PDF]
, 1956 Hannah Rice
openalex +1 more source
A deflated Schur complement method for the iterative solution of a high-order discontinuous element discretization of the Poisson equation [PDF]
arXiv, 2016 A combination of block-Jacobi and deflation preconditioning is used to solve a high-order discontinuous element-based collocation discretization of the Schur complement of the Poisson-Neumann system as arises in the operator splitting of the incompressible Navier-Stokes equations.
arxiv
Frontiers in Immunology, 2017 The innate immune response is evolutionary conserved among organisms. The complement system forms an important and efficient immune defense mechanism. It consists of plasma proteins that participate in microbial detection, which ultimately results in the
U. Shokal, I. Eleftherianos
semanticscholar +1 more source
Editorial: The complement system in autoimmunity
Frontiers in Immunology, 2022 Eveline Y. Wu +6 more
doaj +1 more source
Dysregulation of complement system in neuropsychiatric disorders: A mini review
Biomarkers in Neuropsychiatry, 2022 Complement system is one of the most important defense mechanisms of the innate immune system. In addition to their roles in immune regulation, complement proteins are also involved in neurodevelopment and adult brain plasticity. Complement dysregulation
Danny Perez Sierra +2 more
doaj
INTERACTIONS OF THE COMPLEMENT SYSTEM WITH ENDOTOXIC LIPOPOLYSACCHARIDE: CONSUMPTION OF EACH OF THE SIX TERMINAL COMPLEMENT COMPONENTS [PDF]
, 1968 H Gewurz, H S Shin, S. E. Mergenhagen
openalex +1 more source
Effective Implementation of the Weak Galerkin Finite Element Methods for the Biharmonic Equation [PDF]
arXiv, 2016 The weak Galerkin (WG) methods have been introduced in the references [11, 16] for solving the biharmonic equation. The purpose of this paper is to develop an algorithm to implement the WG methods effectively. This can be achieved by eliminating local unknowns to obtain a global system with significant reduction of size.
arxiv