Results 161 to 170 of about 1,778,418 (315)

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Complement C4, C4A and C4a – What they do and how they differ

Brain, Behavior, & Immunity - Health
Meike Heurich, Melanie Föcking, David Cotter   +2 more
doaj   +1 more source

The complement system in intestinal inflammation and cancer. [PDF]

J Clin Invest
Krieg C, Guglietta S.
europepmc   +1 more source

Mononuclear phagocyte system complement receptor dysfunction in rheumatoid arthritis. [PDF]

, 1987
Robert P. Kimberly, Nancy L. Meryhew, Olaf Runquist   +2 more
openalex   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

The complement system in human pregnancy and preeclampsia. [PDF]

Front Immunol
Kumar V, Stewart JH.
europepmc   +1 more source

Rapid detection of leukemia cells by use of a complement-mediated cytolytic reaction and an imaging sensor system. [PDF]

, 1987
Masayasu Suzuki, Eiichi Tamiya, Tateshi Kataoka, T Tokunaga, Isao Karube   +4 more
openalex   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Complement System Inhibitors in Nephrology: An Update-Narrative Review. [PDF]

Int J Mol Sci
Apetrii M, Costache AD, Costache Enache II, Voroneanu L, Covic AS, Kanbay M, Covic A.   +6 more
europepmc   +1 more source

Interactions of C-reactive protein with the complement system. III. Complement-dependent passive hemolysis initiated by CRP.

, 1975
Alexander P. Osmand, Richard F. Mortensen, J N Siegel, H Gewurz   +3 more
openalex   +1 more source