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Evolution of the complement system
Current Opinion in Immunology, 2001The mammalian complement system constitutes a highly sophisticated body defense machinery comprising more than 30 components. Research into the evolutionary origin of the complement system has identified a primitive version composed of the central component C3 and two activation proteases Bf and MASP in cnidaria.
Masaru Nonaka, Fumiko Yoshizaki
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Journal of Burn Care & Rehabilitation, 1981
Although it is still not possible to integrate completely the various components involved in the inflammatory response, we now have the capability of indicating some of the effector pathways and identifying a number of points of interaction between them.
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Although it is still not possible to integrate completely the various components involved in the inflammatory response, we now have the capability of indicating some of the effector pathways and identifying a number of points of interaction between them.
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The complement system and systemic sclerosis
Immunologic Research, 1993Serum concentrations of the various complement components including the classical and the alternative pathways were determined in 58 control healthy subjects and 80 patients with systemic sclerosis (SSC). The mean concentrations of C1q, C2, C5, C6, C7, C9, and factor B were significantly increased in the SSC patients in comparison to controls, while ...
M. Schlesinger +6 more
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1993
Bordet, when working in Pasteur’S laboratory in Paris in 1896, observed that serum of animals immunized with bacteria (Vibrio cholerae), could agglutinate and lyse those bacteria in vitro (either in a test tube or on a slide). If, however, the serum was left at room temperature for one week, or briefly heated at 60 °C, the agglutinating activity ...
M. A. McAleer, Robert B. Sim
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Bordet, when working in Pasteur’S laboratory in Paris in 1896, observed that serum of animals immunized with bacteria (Vibrio cholerae), could agglutinate and lyse those bacteria in vitro (either in a test tube or on a slide). If, however, the serum was left at room temperature for one week, or briefly heated at 60 °C, the agglutinating activity ...
M. A. McAleer, Robert B. Sim
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2018
The complement system consists of a complex cascade of zymogens that leads to the formation of opsonins (predominantly C3b and C4b) that promote phagocytosis and the insertion of the membrane attack complex into the membranes, resulting in lysis. It constitutes one of the first lines of defense against pathogens as it does not require prior maturation ...
José A. Stoute, Sergei Biryukov
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The complement system consists of a complex cascade of zymogens that leads to the formation of opsonins (predominantly C3b and C4b) that promote phagocytosis and the insertion of the membrane attack complex into the membranes, resulting in lysis. It constitutes one of the first lines of defense against pathogens as it does not require prior maturation ...
José A. Stoute, Sergei Biryukov
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1999
Throughout the ages man has been fascinated and at times obsessed by the marvelous, mysterious and even baffling qualities of the blood. In 1889, Hans Buchner described a heat-labile bactericidal principle in the blood which was later identified as the complement system. In 1894, Jules Bordet working at the Pasteur Institute in Metchnikoff’s laboratory
Robert E. Lewis, Julius M. Cruse
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Throughout the ages man has been fascinated and at times obsessed by the marvelous, mysterious and even baffling qualities of the blood. In 1889, Hans Buchner described a heat-labile bactericidal principle in the blood which was later identified as the complement system. In 1894, Jules Bordet working at the Pasteur Institute in Metchnikoff’s laboratory
Robert E. Lewis, Julius M. Cruse
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The complement system of the duck
Avian Pathology, 1999Antibody (Ab)-dependent and-independent activation of the duck complement (C') system were studied. Ab-independent C' activity exhibited characteristics similar to those of the mammalian alternative C' pathway (ACP), including the selective lysis of rabbit erythrocytes (RRBC), a requirement for Mg2+, but not Ca2+, depletion of activity by zymosan, and ...
Sarah W. S. Chan +2 more
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The Complement System in Uremia
Scandinavian Journal of Urology and Nephrology, 1980Plasma C1q, C1 esterase inactivator, C4, C3 and C3 proactivator were measured in 20 chronic uremic patients on maintenance hemodialysis, in 10 conservatively treated chronic uremic patients and in 20 healthy volunteers. There was no statistical significant difference between the patient groups in any of the measured complement components.
Erik Stoffersen, K. Anker Jørgensen
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Pathways to the Complement System
New England Journal of Medicine, 1972IT has been well appreciated for many years that the serum complement system, through the concerted action of all its components, is a prime mediator of cytotoxic injury to antibody-sensitized cell...
Fred S. Rosen, Irwin H. Lepow
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