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Introduction to the complement system
Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1984Abstract Complement is the essential effector mechanism in humoral immunity to infection. Combination of antibody with antigen causes cross-linking, leading to precipitation of soluble antigens and agglutination of particular antigens, but no more.
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The Complement System and Inflammation
1979The complement system was discovered toward the end of the nineteenth century as a heat-labile principle in fresh nonimmune serum which was essential for the bactericidal activity of serum from immunized guinea pigs. It has subsequently been established as a very important factor of constitutive immunity. The complement system functions as an auxiliary
J O, Minta, H Z, Movat
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Control of the Complement System
1996The complement system has developed a remarkably simple but elegant manner of regulating itself. It has faced and successfully dealt with how to facilitate activation on a microbe while preventing the same on host tissue. It solved this problem primarily by creating a series of secreted and membrane-regulatory proteins that prevent two highly ...
M K, Liszewski +4 more
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Targeting the complement system
Current Opinion in Nephrology and Hypertension, 1999Interest has blossomed in the development of complement inhibitors, in parallel with a growth in our understanding of the biology of the complement cascade. The first generation of designed inhibitors was based on naturally occurring complement receptors and regulatory molecules.
J E, Marsh, J R, Pratt, S H, Sacks
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The complement system of the duck
Avian Pathology, 1999Antibody (Ab)-dependent and-independent activation of the duck complement (C') system were studied. Ab-independent C' activity exhibited characteristics similar to those of the mammalian alternative C' pathway (ACP), including the selective lysis of rabbit erythrocytes (RRBC), a requirement for Mg2+, but not Ca2+, depletion of activity by zymosan, and ...
T L, Koppenheffer +2 more
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Evolution of the complement system
Immunology Today, 1991The ancestral form of the alternative pathway of complement activation probably originated as a primitive independent immune system. Subsequent evolution of an adaptive immune response drove the specialization of the classical pathway to connect antibody-mediated nonself recognition to the complement-dependent effector mechanisms.
T C, Farries, J P, Atkinson
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Serpins and the Complement System
2011C1-inhibitor (serpin G1) is a 105 kDa inhibitor which functions as a major antiinflammatory protein in the body. It has its effects via inhibition of the proteases of the complement system and contact system of coagulation, as well as several direct effects mediated by its unique highly glycosylated N-terminal domain.
László, Beinrohr +6 more
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The Complement System in Pregnancy
American Journal of Reproductive Immunology, 1983Maternal recognition of fetal antigens is well-documented. Antibodies directed against fetal antigens are the rule rather than the exception. Maternal antibodies seem to bind fetal antigens at the placental level and apparently activate the complement system even in normal pregnancy, yet multiple studies confirm an increase in C1q, C4, C3 and CH50 ...
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Complement and complement regulators in the male reproductive system
Molecular Immunology, 2006Spermatozoa are almost unique among cells in that they must survive transplantation into a foreign host in order to perform their physiological role. The biggest hurdle to overcome is innate immune defence that will target the invaders in the female genital tract.
Claire L, Harris +2 more
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The complement system in xenotransplantation
Immunopharmacology, 1992The immediate barrier to xenotransplantation across phylogenetically distant species, a manifestation of natural immunity, is hyperacute rejection of the xenograft. Complement (C) plays a central pathophysiological role in hyperacute rejection. Hyperacute rejection is initiated when C is activated by natural antibodies against the vascular endothelium ...
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