Results 61 to 70 of about 1,195,438 (288)
Molecular Oncology, EarlyView.Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran +16 more
wiley +1 more source
Complement System and C4d expression in cases of Membranous nephropathy
Brazilian Journal of NephrologyIntroduction: Membranous nephropathy (MN) is one of the major causes of nephrotic syndrome. The complement system plays a key role in the pathophysiology of MN.
Fabiano Bichuette Custódio +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou +11 more
wiley +1 more source
Flowlines transverse to fibred knots and links [PDF]
arXiv, 2003 We consider vector fields on knot/link complements in $S^3$ which are transverse to the fibres of a fibration of the complement over a circle. We prove that a large class of fibred knots/links, including all non-torus fibred 2-bridge knots, has the following property: any vector field transverse to the fibres of the fibration of the complement must ...
arxiv
Molecular Oncology, EarlyView.Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti +8 more
wiley +1 more source
On the cohomology of discriminantal arrangements and Orlik-Solomon algebras [PDF]
arXiv, 1999 We relate the cohomology of the Orlik-Solomon algebra of a discriminantal arrangement to the local system cohomology of the complement. The Orlik-Solomon algebra of such an arrangement (viewed as a complex) is shown to be a linear approximation of a complex arising from the fundamental group of the complement, the cohomology of which is isomorphic to ...
arxiv
Molecular Oncology, EarlyView.Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley +1 more source
COMPLEMENT SYSTEM AS A MARKER OF IMMUNE DYSFUNCTION IN CHILDREN AUTISM SPECTRUM DISORDERS
Медицинская иммунология, 2019 It is known that functional activity of complement system depends not only on balance and concentration of components participating in formation of the system end products, but also on levels of inhibitory activities.
E. G. Cheremnykh +6 more
doaj +1 more source
Cohomology of the complement to an elliptic arrangement [PDF]
arXiv, 2011 We consider the complement to an arrangement of hyperplanes in a cartesian power of an elliptic curve and describe its cohomology with coefficients in a nontrivial rank one local system.
arxiv
Molecular Oncology, EarlyView.MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin +14 more
wiley +1 more source