Results 91 to 100 of about 2,103,871 (307)

Balancing selection on the complement system of a wild rodent

BMC Ecology and Evolution, 2023
Background Selection pressure exerted by pathogens can influence patterns of genetic diversity in the host. In the immune system especially, numerous genes encode proteins involved in antagonistic interactions with pathogens, paving the way for ...
Mridula Nandakumar, Max Lundberg, Fredric Carlsson, Lars Råberg   +3 more
doaj   +1 more source

Persistent complement dysregulation with signs of thromboinflammation in active Long Covid

Science
Long Covid is a debilitating condition of unknown etiology. We performed multimodal proteomics analyses of blood serum from COVID-19 patients followed up to 12 months after confirmed severe acute respiratory syndrome coronavirus 2 infection. Analysis of >
Carlo Cervia-Hasler, S. Brüningk, Tobias Hoch, Bowen Fan, Giulia Muzio, Ryan C. Thompson, Laura Ceglarek, Roman Meledin, Patrick Westermann, M. Emmenegger, Patrick Taeschler, Yves Zurbuchen, Michele Pons, D. Menges, T. Ballouz, Sara Cervia-Hasler, Sarah Adamo, Miram Merad, Alexander W. Charney, M. Puhan, P. Brodin, J. Nilsson, Adriano Aguzzi, M. E. Raeber, Christoph B. Messner, N. Beckmann, Karsten M. Borgwardt, O. Boyman   +27 more
semanticscholar   +1 more source

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source

Complement Evasion Strategies of Viruses: An Overview

Frontiers in Microbiology, 2017
Being a major first line of immune defense, the complement system keeps a constant vigil against viruses. Its ability to recognize large panoply of viruses and virus-infected cells, and trigger the effector pathways, results in neutralization of viruses ...
Palak Agrawal, Renuka Nawadkar, Hina Ojha, Jitendra Kumar, Arvind Sahu   +4 more
doaj   +1 more source

Characterization of early and terminal complement proteins associated with polymorphonuclear leukocytes in vitro and in vivo after spinal cord injury [PDF]

, 2008
Background The complement system has been suggested to affect injury or disease of the central nervous system (CNS) by regulating numerous physiological events and pathways.
Anderson, Aileen J, Galvan, Manuel D, Nguyen, Hal X   +2 more
core   +3 more sources

Functional Genomics of Tick Thioester-Containing Proteins Reveal the Ancient Origin of the Complement System

Journal of Innate Immunity, 2011
Ticks are important ectoparasites and vectors of multiple human and animal diseases. The obligatory hemophagy of ticks provides a formidable route for parasite transmission from one host to another. Parasite survival inside the tick relies on the ability
V. Burešová, O. Hajdušek, Z. Franta, G. Loosova, Lenka Grunclová, E. Levashina, P. Kopáček   +6 more
semanticscholar   +1 more source

Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors

Molecular Oncology, EarlyView.
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi, Janelle‐Cheri Millen, Romela Irene Ramos, Jennifer A. Linehan, Timothy G. Wilson, Dave S. B. Hoon, Matias A. Bustos   +6 more
wiley   +1 more source

Expressão de proteínas reguladoras do complemento CD55, CD59, CD35 e CD46 na artrite reumatoide Expression of complement regulatory proteins CD55, CD59, CD35, and CD46 in rheumatoid arthritis

Revista Brasileira de Reumatologia, 2011
A artrite reumatoide (AR) é uma doença autoimune, associada à sinovite poliarticular inflamatória, que acomete principalmente as articulações periféricas.
Amanda Kirchner Piccoli, Ana Paula Alegretti, Laiana Schneider, Priscila Schmidt Lora, Ricardo Machado Xavier   +4 more
doaj   +1 more source

Complement System in the Pathogenesis of Benign Lymphoepithelial Lesions of the Lacrimal Gland. [PDF]

PLoS ONE, 2016
We aimed to examine the potential involvement of local complement system gene expression in the pathogenesis of benign lymphoepithelial lesions (BLEL) of the lacrimal gland.We collected data from 9 consecutive pathologically confirmed patients with BLEL ...
Jing Li, Xin Ge, Xiaona Wang, Xiao Liu, Jianmin Ma   +4 more
doaj   +1 more source

High glucose disrupts oligosaccharide recognition function via competitive inhibition : a potential mechanism for immune dysregulation in diabetes mellitus [PDF]

, 2011
Diabetic complications include infection and cardiovascular disease. Within the immune system, host-pathogen and regulatory host-host interactions operate through binding of oligosaccharides by C-type lectin.
Ahmed, Bee K. Tan, Botto, Bouyain, Caparros, Carlow, Ceriello, Chaipan, Daniel A. Mitchell, Daniel Zehnder, Devaraj, Elizabeth J. Soilleux, Feinberg, Fernandez-Real, Geijtenbeek, Geijtenbeek, Geijtenbeek, Ghanim, Gringhuis, Guo, Harpal S. Randeva, Held, Hendrik Lehnert, Holman, Ip, Krutzik, Lee, Lillegard, Mitchell, Moller-Kristensen, Nauta, Paidassi, Paul Townsend, Permana, Pohlmann, Reading, Rebecca Ilyas, Robert B. Sim, Russell Wallis, Savill, Schilder, Seelen, Soilleux, Strong, Stuart, Turner, Turner, UKPDS, Wallis, Walport, Walport, Weis, Weis, Worthley, Zeyda   +54 more
core   +1 more source