Results 201 to 210 of about 547,306 (324)

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin, Haocheng Yang, Feng Liu, Sihao Lin, Junru Hu, Jian Wang, Yulan Gou   +6 more
wiley   +1 more source

Do microenvironmental changes in degenerative disc disease reflect in systemic circulation? A proteomic investigation. [PDF]

Clin Proteomics
Nayagam SM, Palraj ND, Eswaran M, Selvaraj G, Rajendran S, Ramachandran K, Arunachalam D, Tangavel C, K S SA, Raveendran M, Rajasekaran S.   +10 more
europepmc   +1 more source

Ig-binding surface proteins of Streptococcus pyogenes also bind human C4b-binding protein (C4BP), a regulatory component of the complement system. [PDF]

, 1995
Anette Thern, Lars Stenberg, Björn Dahlbäck, Gunnar Lindahl   +3 more
openalex   +1 more source

Impact of Stress‐Induced Hyperglycemia on In‐Hospital Medical Complications in Patients With Acute Stroke: From a Large‐Scale Nationwide Longitudinal Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Aims This study aimed to explore the relationship between stress‐induced hyperglycemia (SIH) and in‐hospital medical complications in patients with acute stroke. Methods We enrolled 865,765 patients with acute stroke from the Chinese Stroke Center Alliance cohort.
Xintong Song, Yi Ju, Hongqiu Gu, Zhikai Zhu, Zixiao Li, Qian Zhang, Xingquan Zhao   +6 more
wiley   +1 more source

The complement cascade in Alzheimer's disease: modern implications of an ancient immune protagonist. [PDF]

Mol Neurodegener
Papavergi MT, Bathini P, Singh B, Lemere CA.   +3 more
europepmc   +1 more source

Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan, John R. Mills, Paulina Vargas, Naveen K. Paramasivan, Connie E. Lesnick, Eati Basal, Surendra Dasari, James P. Fryer, Shannon R. Hinson, Joseph Laporta, Amy Espinal, Dennis Fitzgerald, Carolina Garcia, Anna E. Morenkova, Paola Pergami, Anna Shah, Andrew Knight, Reghann LaFrance Corey, Vanda A. Lennon, Anastasia Zekeridou, Sean J. Pittock, Divyanshu Dubey, Andrew McKeon   +22 more
wiley   +1 more source

Complement activation in immunological neurological disorders: mechanisms and therapeutic strategies. [PDF]

Front Neurol
Chen JY, Sanghani N, Palmer K, Li Y, Lin F, Abbatemarco JR.   +5 more
europepmc   +1 more source

Comparative structure-function analysis of bromodomain and extraterminal motif (BET) proteins in a gene-complementation system

, 2019
Michael T. Werner, Hong‐Xin Wang, Nicole Hamagami, Sarah Hsu, Jennifer A. Yano, Aaron J. Stonestrom, Vivek Behera, Yichen Zong, Joel P. Mackay, Gerd A. Blobel   +9 more
openalex   +1 more source

Real‐World Investigation of Satralizumab in Patients With Neuromyelitis Optica Spectrum Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Satralizumab, a monoclonal antibody targeting the interleukin‐6 receptor, has demonstrated efficacy in clinical trials for neuromyelitis optica spectrum disorder (NMOSD). However, its real‐world effectiveness and safety compared to conventional immunosuppressive therapies remain uncertain.
Li‐Tsung Lin, Hui‐An Lin, Sheng‐Feng Lin   +2 more
wiley   +1 more source

Dietary Betaine Improves Immune Function, Antioxidant Status, Immune-Related Signaling Molecules, and Disease Resistance in Fish Species. [PDF]

Aquac Nutr
Yousefi M, Molayemraftar T, Hoseini SM, Ghafarifarsani H.   +3 more
europepmc   +1 more source