Results 181 to 190 of about 325,997 (305)

補体学入門 : Cold Activation現象の発見から現在の問題点まで(自然科学系)

, 1997
This short review is for beginners in complementology. The complement system is composed of 30 kinds of physiological proteins: 14 serum complement components; 6 serum inhibitors; 4 membrane inhibitors; and 6 complement receptors on the cellular membrane.
北村, 肇, Kitamura, Hajime
core  

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

An Iron-Complement Network Model of Thromboinflammation and Humoral Immune Remodeling in Severe COVID-19. [PDF]

Curr Issues Mol Biol
Chen Z, Wang S, Chen Y.
europepmc   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Sera from Phylogenetically Related Alligators, Crocodiles and Domestic Chickens Exhibit Comparable Anti-Cancer Activity. [PDF]

Cells
Binah O, Shalev G, Maor G, Reiter I, Ziv I, Ciechanover A.   +5 more
europepmc   +1 more source

Serum proteins of complement system

Japanese Journal of Clinical Chemistry, 1973
openaire   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Clearance of Early Complement Protein From CSF After Aneurysmal Subarachnoid Hemorrhage and Influence on Neurologic Outcome. [PDF]

Neurol Neuroimmunol Neuroinflamm
Geraghty JR, Katz EA, Butler M, Testai FD.   +3 more
europepmc   +1 more source

Human complement factor B: functional properties of a recombinant zymogen of the alternative activation pathway convertase [PDF]

, 1993
Estaller, C., Tobias Sokolowski, Cornelia Estaller, Birgit Lüttig, Dippold, W., Karl-Hermann Meyer zum Büschenfelde, Whaley, K., Keith Whaley, Wolfgang Dippold, Elisabeth H. Weiss, Schwaeble, W., Luttig, B., Meyer zum Buschenfelde, K. H., Weiss, Elisabeth H., Wilhelm Schwaeble, Sokolowski, T.   +15 more
core   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source