The Kaposi's Sarcoma-associated Herpesvirus Complement Control Protein Mimics Human Molecular Mechanisms for Inhibition of the Complement System [PDF]
Journal of Biological Chemistry, 2004 Kaposi's sarcoma-associated human herpesvirus (KSHV) is thought to cause Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. Previously, we reported that the KSHV complement control protein (KCP) encoded within the viral genome is a potent regulator of the complement system; it acts both as a cofactor for factor I and ...
O. Brad Spiller +6 more
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The Complement System: A Prey of Trypanosoma cruzi
Frontiers in Microbiology, 2017 Trypanosoma cruzi is a protozoan parasite known to cause Chagas disease (CD), a neglected sickness that affects around 6–8 million people worldwide. Originally, CD was mainly found in Latin America but more recently, it has been spread to countries in ...
Kárita C. F. Lidani +3 more
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In vivo protein stabilization based on fragment complementation and a split GFP system [PDF]
Proceedings of the National Academy of Sciences, 2010 Protein stabilization was achieved through in vivo screening based on the thermodynamic linkage between protein folding and fragment complementation. The split GFP system was found suitable to derive protein variants with enhanced stability due to the correlation between effects of mutations on the stability of the intact chain and the effects of the ...
Stina Lindman +4 more
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Sites of Production of Primate Serum Proteins Associated with the Complement System.
Experimental Biology and Medicine, 1967 SummaryVarious human and monkey tissues, including liver, spleen, bone marrow, and lung were found to incorporate C14-amino acids into 11S globulin (C′1q) in vitro. A comparison with previous studies on β10 (C′3) and 1β1E (C′4) production revealed a striking similarity in the sites of synthesis of these 3 proteins.
Morse Jh, Stecher Vj, G. J. Thorbecke
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Heat shock protein 70 is a potent activator of the human complement system [PDF]
Cell Stress & Chaperones, 2002 According to new hypotheses, extracellular heat shock proteins (Hsps) may represent an ancestral danger signal of cellular death or lysis-activating innate immunity. Recent studies demonstrating a dual role for Hsp70 as both a chaperone and cytokine, inducing potent proinflammatory response in human monocytes, provided support for the hypothesis that ...
Prohászka, Zoltán +6 more
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Synovial fibroblast‐like cells synthesize seven proteins of the complement system [PDF]
Arthritis & Rheumatism, 1988 AbstractFibroblast‐like cells from synovial tissue obtained during arthroscopy in 4 young adults with recent knee trauma were biosynthetically labeled with 35S‐methionine, and protein production was quantitated by immunoprecipitation and sodium dodecyl sulfate—polyacrylamide gel electrophoresis.
Yitzhak Katz, Robert C. Strunk
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Rat C‐reactive protein activates the autologous complement system
Immunology, 2003 SummaryActivation of complement is a biological function of human C‐reactive protein (hCRP), whereas rat CRP (rCRP) has been claimed to be unable to activate complement. As important biological functions of proteins are probably conserved among species, we re‐evaluated, using various ligands, the capability of rCRP to activate complement.
Wim K. Bleeker +6 more
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Genetic Polymorphism in Proteins of the Complement System [PDF]
Korean Journal of Transplantation, 2016 Dobeen Hwang +10 more
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Complement System Proteins in the Human Aqueous Humor and Their Association with Primary Open-Angle Glaucoma. [PDF]
J Pers Med, 2023 Vashishtha A +11 more
europepmc +3 more sources
Low serum complement level is associated with higher mortality in tuberculous meningitis: a retrospective cohort study [PDF]
Encephalitis, 2023 Purpose We evaluated the associations between serum complement levels and tuberculous meningitis (TBM), bacterial meningitis (BM), and viral meningitis (VM), as well as the association between serum complement levels and mortality in TBM.
Hansol Im +7 more
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