Results 51 to 60 of about 310,548 (243)
Emerging Roles of Complement in Psychiatric Disorders
Frontiers in Psychiatry, 2019 The complement system consists of more than 30 proteins that have long been known to participate to the immune defence against pathogens and to the removal of damaged cells.
Mélanie Druart +5 more
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Sites of Production of Primate Serum Proteins Associated with the Complement System.
Experimental Biology and Medicine, 1967 SummaryVarious human and monkey tissues, including liver, spleen, bone marrow, and lung were found to incorporate C14-amino acids into 11S globulin (C′1q) in vitro. A comparison with previous studies on β10 (C′3) and 1β1E (C′4) production revealed a striking similarity in the sites of synthesis of these 3 proteins.
Stecher, V. J. +2 more
openaire +2 more sources
Frontiers in Immunology, 2023 The complement system is implicated in a broad range of neuroinflammatory disorders such as Alzheimer’s disease (AD) and multiple sclerosis (MS). Consequently, measuring complement levels in biofluids could serve as a potential biomarker for these ...
Marlies Burgelman +7 more
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Frontiers in Immunology, 2018 The alternative pathway is a continuously active surveillance arm of the complement system, and it can also enhance complement activation initiated by the classical and the lectin pathways.
Pilar Sánchez-Corral +5 more
doaj +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
The regulatory C proteins from different restriction-modification systems can cross-complement [PDF]
Journal of Bacteriology, 1995 The BamHI restriction-modification system contains a third gene, bamHIC, which positively regulates bamHIR. Similar small genes from other systems were tested in vivo for their ability to cross-complement. C.BamHI protein was identified, purified, and used to raise polyclonal antibodies.
C L, Ives, A, Sohail, J E, Brooks
openaire +2 more sources
The Complement System: A Prey of Trypanosoma cruzi
Frontiers in Microbiology, 2017 Trypanosoma cruzi is a protozoan parasite known to cause Chagas disease (CD), a neglected sickness that affects around 6–8 million people worldwide. Originally, CD was mainly found in Latin America but more recently, it has been spread to countries in ...
Kárita C. F. Lidani +3 more
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Balancing selection on the complement system of a wild rodent
BMC Ecology and Evolution, 2023 Background Selection pressure exerted by pathogens can influence patterns of genetic diversity in the host. In the immune system especially, numerous genes encode proteins involved in antagonistic interactions with pathogens, paving the way for ...
Mridula Nandakumar +3 more
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