Results 51 to 60 of about 2,103,871 (307)

SARS-CoV-2 Exacerbates COVID-19 Pathology Through Activation of the Complement and Kinin Systems

Frontiers in Immunology, 2021
Infection with SARS-CoV-2 triggers the simultaneous activation of innate inflammatory pathways including the complement system and the kallikrein-kinin system (KKS) generating in the process potent vasoactive peptides that contribute to severe acute ...
Anne G. Savitt, Anne G. Savitt, Samantha Manimala, Tiara White, Tiara White, Marina Fandaros, Wei Yin, Huiquan Duan, Xin Xu, Brian V. Geisbrecht, David A. Rubenstein, Allen P. Kaplan, Ellinor I. Peerschke, Berhane Ghebrehiwet   +13 more
doaj   +1 more source

Assessing the relevance of node features for network structure [PDF]

PNAS 106, 11433 (2009), 2008
Networks describe a variety of interacting complex systems in social science, biology and information technology. Usually the nodes of real networks are identified not only by their connections but also by some other characteristics. Examples of characteristics of nodes can be age, gender or nationality of a person in a social network, the abundance of
arxiv   +1 more source

Preferential association of hepatitis C virus with CD19+ B cells is mediated by complement system [PDF]

, 2016
Extrahepatic disease manifestations are common in chronic hepatitis C virus (HCV) infection. The mechanism of HCV-related lymphoproliferative disorders is not fully understood.
Alter, Harvey J., Baré, Patricia, De Giorgi, Valeria, Grandinetti, Teresa, Matsuura, Kentaro, Salam, Kazi Abdus, Schechterly, Cathy, Wang, Richard   +7 more
core   +1 more source

Elevated CSF and plasma complement proteins in genetic frontotemporal dementia: results from the GENFI study [PDF]

, 2023
Neuroinflammation is emerging as an important pathological process in frontotemporal dementia (FTD), but biomarkers are lacking. We aimed to determine the value of complement proteins, which are key components of innate immunity, as biomarkers in ...
Bocchetta M, Borroni B, Bouzigues A, Butler C, Cash D, Danek A, de Mendonça A, Dopper EGP, Ducharme S, Finger E, Galimberti D, Gerhard A, Graff C, Heller C, Jiskoot LC, Laforce R, Levin J, Masellis M, McFall D, Meeter LH, Moreno F, Otto M, Panman JL, Papma JM, Peakman G, Pijnenburg YAL, Poos JM, Rowe JB, Sanchez-Valle R, Santana I, Sogorb-Esteve A, Sorbi S, Swift IJ, Synofzik M, Tagliavini F, Tartaglia MC, Todd E, van der Ende EL, Vandenberghe R, Zetterberg H   +39 more
core   +1 more source

Proteins of the lectin pathway of the complement system activation: immunobiological functions, genetics and involvement in the pathogenesis of human diseases

Инфекция и иммунитет, 2022
The complement system is the most ancient components in the innate immunity, mainly functioning to primarily eliminate bacterial agents intravascularly.
Marina V. Smolnikova, Sergey Yu. Tereshchenko   +1 more
doaj   +1 more source

Therapeutic Inhibition of the Complement System in Diseases of the Central Nervous System

Frontiers in Immunology, 2019
The complement system plays critical roles in development, homeostasis, and regeneration in the central nervous system (CNS) throughout life; however, complement dysregulation in the CNS can lead to damage and disease.
Sarah M Carpanini, Megan Torvell, B. Morgan   +2 more
semanticscholar   +1 more source

Elastohydrodynamics and kinetics of protein patterning in the immunological synapse [PDF]

, 2015
The cellular basis for the adaptive immune response during antigen recognition relies on a specialized protein interface known as the immunological synapse (IS). Understanding the biophysical basis for protein patterning by deciphering the quantitative rules for their formation and motion is an important aspect of characterizing immune cell recognition
arxiv   +1 more source

Complement System and C4d expression in cases of Membranous nephropathy

Brazilian Journal of Nephrology
Introduction: Membranous nephropathy (MN) is one of the major causes of nephrotic syndrome. The complement system plays a key role in the pathophysiology of MN.
Fabiano Bichuette Custódio, Crislaine Aparecida da Silva, Fernanda Rodrigues Helmo, Juliana Reis Machado, Marlene Antônia dos Reis   +4 more
doaj   +1 more source

Zika Virus Infection Modulates Expression of Regulatory Complement Factors in SH-SY5Y Cells [PDF]

, 2020
Viruses that use the blood as a route of systemic spread frequently encode proteins allowing evasion of the complement system. Although complement neutralizes pathogens in the blood, the complement system has non-immune functions in the central nervous ...
Yeung, Jason
core  

Measuring Total Classical Pathway and Activities of Individual Components of the Mouse Complement Pathway

Bio-Protocol, 2021
The complement system is a central component of innate immunity, responsible for recognition and killing of bacteria by tagging invaders through opsonisation, thereby promoting phagocytosis, and by direct lysis.
Wioleta Zelek
doaj   +1 more source