Results 51 to 60 of about 2,132,131 (391)

Factor H family proteins and human diseases [PDF]

, 2008
Complement is a major defense system of innate immunity and aimed to destroy microbes. One of the central complement regulators is factor H, which belongs to a protein family that includes CFHL1 and five factor H-related (CFHR) proteins.
Abrera-Abeleda, Anderson, Appel, Behnsen, Caswell, Coffey, Corbett, Cordes, Crabb, Dragon-Durey, Ferreira, Gold, Hageman, Hageman, Hammerschmidt, Haupt, Heinen, Hellwage, Hellwage, Hellwage, Hughes, Høgåsen, Jokiranta, Józsi, Józsi, Józsi, Józsi, Kavanagh, Klein, Kotarsky, Kotarsky, Kraiczy, Kunert, Laine, Lambris, Licht, Manuelian, Markiewski, McArthur, McDowell, McRae, Mihály Józsi, Montalvo, Monteferrante, Murphy, Ngampasutadol, Noris, Nozaki, Närkiö-Mäkelä, Oppermann, Pandiripally, Park, Peter F. Zipfel, Pickering, Pickering, Prodinger, Ren, Rodríguez de Córdoba, Skerka, Skerka, Stevenson, Timmann, Venables, Verma, Vik, Walport, Yates, Zipfel, Zipfel, Zipfel   +69 more
core   +1 more source

Structure-Guided Engineering of a Complement Component C3-Binding Nanobody Improves Specificity and Adds Cofactor Activity

Frontiers in Immunology, 2022
The complement system is a part of the innate immune system, where it labels intruding pathogens as well as dying host cells for clearance. If complement regulation is compromised, the system may contribute to pathogenesis.
Henrik Pedersen, Rasmus Kjeldsen Jensen, Annette Gudmann Hansen, Steen Vang Petersen, Steffen Thiel, Nick Stub Laursen, Nick Stub Laursen, Gregers Rom Andersen   +7 more
doaj   +1 more source

Proteins of the SubB family provide multiple mechanisms of serum resistance in <i>Yersinia pestis</i>. [PDF]

Emerg Microbes Infect
The serum complement system is a cornerstone element of the innate immune response. Bacterial resistance to this system is a multifaceted process involving various proteins and molecular mechanisms.
Pierre F, Baillez A, Dewitte A, Rolandelli A, Sebbane F.   +4 more
europepmc   +2 more sources

Complement Fixation in the C-reactive Protein System

Experimental Biology and Medicine, 1954
SummaryA complement fixation method based on the reaction between CRP in human test sera and rabbit CRP antisera has been described.
Robert J. Weatherwax, Louis H. Muschel
openaire   +3 more sources

Preferential association of hepatitis C virus with CD19+ B cells is mediated by complement system [PDF]

, 2016
Extrahepatic disease manifestations are common in chronic hepatitis C virus (HCV) infection. The mechanism of HCV-related lymphoproliferative disorders is not fully understood.
Alter, Harvey J., Baré, Patricia, De Giorgi, Valeria, Grandinetti, Teresa, Matsuura, Kentaro, Salam, Kazi Abdus, Schechterly, Cathy, Wang, Richard   +7 more
core   +1 more source

The function of adipsin and C9 protein in the complement system in HIV-associated preeclampsia [PDF]

Archives of Gynecology and Obstetrics, 2021
In preeclampsia, there are excessive complement components expressed due to increased complement activation; therefore, this study investigated the concentration of adipsin and C9 in HIV-associated preeclampsia.The study population (n = 76) was stratified by pregnancy type (normotensive pregnant and preeclampsia) and by HIV status.
Mikyle David, Jagidesa Moodley, Thajasvarie Naicker   +2 more
openaire   +2 more sources

Tah1 helix-swap dimerization prevents mixed Hsp90 co-chaperone complexes [PDF]

, 2015
Specific co-chaperone adaptors facilitate the recruitment of client proteins to the Hsp90 system. Tah1 binds the C-terminal conserved MEEVD motif of Hsp90, thus linking an eclectic set of client proteins to the R2TP complex for their assembly and ...
Ali, Back, Battye, Boulon, Chartron, Chrisostomos Prodromou, Eckert, Emsley, Forget, Gonzales, Hořejší, Itsuki, Izumi, Jiménez, Kakihara, Krissinel, Kurokawa, Laurence H. Pearl, Liou, Liu, Mohinder Pal, Morgan, Murshudov, Nagradova, Nyarko, Pal, Pearl, Polier, Prodromou, Prodromou, Rhodri M. L. Morgan, Roe, S. Mark Roe, Samarsky, Siligardi, Takai, Te, Tobaben, Tung, Vaughan, Worrall, Zhang, Zhao   +42 more
core   +1 more source

Evaluation of nonionic and zwitterionic detergents as membrane protein solubilizers in two-dimensional electrophoresis [PDF]

Proteomics 3 (03/2003) 249-53, 2006
The solubilizing power of various nonionic and zwitterionic detergents as membrane protein solubilizers for two-dimensional electrophoresis was investigated. Human red blood cell ghosts and Arabidopsis thaliana leaf membrane proteins were used as model systems. Efficient detergents could be found in each class, i.e.
arxiv   +1 more source

Overview of Complement Activation and Regulation [PDF]

, 2013
SummaryComplement is an important component of the innate immune system that is crucial for defense from microbial infections and for clearance of immune complexes and injured cells.
Noris, Marina, Remuzzi, Giuseppe
core   +1 more source

A novel trifunctional IgG-like bispecific antibody to inhibit HIV-1 infection and enhance lysis of HIV by targeting activation of complement [PDF]

, 2010
BACKGROUND: The complement system is not only a key component of innate immunity but also provides a first line of defense against invading pathogens, especially for viral pathogens.
Chuanfu Zhang, Fei Qiao, Hongbin Song, Huihui Chong, Leili Jia, Ligui Wang, Shaofu Qiu, Stephen Tomlinson, Weijing Liu, Yansong Sun, Yanwei Zhong, Yong Wang, Yuanyong Xu, Yusen Zhou, Yuxian He   +14 more
core   +2 more sources