Factor H family proteins and human diseases [PDF]
Complement is a major defense system of innate immunity and aimed to destroy microbes. One of the central complement regulators is factor H, which belongs to a protein family that includes CFHL1 and five factor H-related (CFHR) proteins.
Abrera-Abeleda+69 more
core +1 more source
Complement and Cancer Immunity [PDF]
The complement system is considered as a crucial mediator of the innate immune mechanisms. its three activation pathways contribute to cellular homeostasis, and protect the host from exogenous pathogens and self-derived components.
and Uday Kishore+3 more
core +1 more source
Evaluation of nonionic and zwitterionic detergents as membrane protein solubilizers in two-dimensional electrophoresis [PDF]
The solubilizing power of various nonionic and zwitterionic detergents as membrane protein solubilizers for two-dimensional electrophoresis was investigated. Human red blood cell ghosts and Arabidopsis thaliana leaf membrane proteins were used as model systems. Efficient detergents could be found in each class, i.e.
arxiv +1 more source
Counterion-release entropy governs the inhibition of serum proteins by polyelectrolyte drugs [PDF]
Dendritic polyelectrolytes constitute high potential drugs and carrier systems for biomedical purposes, still their biomolecular interaction modes, in particular those determining the binding affinity to proteins, have not been rationalized. We study the interaction of the drug candidate dendritic polyglycerol sulfate (dPGS) with serum proteins using ...
arxiv +1 more source
Human complement control and complement evasion by pathogenic microbes - Tipping the balance [PDF]
Complement is a central homeotic system of mammals and represents the first defense line of innate immunity. The human complement system is aimed to maintain homeostasis by recognizing and removing damaged or modified self material, as well as infectious
Hallstroem, Teresia+2 more
core +1 more source
Hijacking Complement Regulatory Proteins for Bacterial Immune Evasion
The human complement system plays an important role in the defense against invading pathogens, inflammation and homeostasis. Invading microbes, such as bacteria, directly activate the complement system resulting in the formation of chemoattractants and ...
Elise Sofie Hovingh+4 more
doaj +1 more source
Bilayer-thickness-mediated interactions between integral membrane proteins [PDF]
Hydrophobic thickness mismatch between integral membrane proteins and the surrounding lipid bilayer can produce lipid bilayer thickness deformations. Experiment and theory have shown that protein-induced lipid bilayer thickness deformations can yield energetically favorable bilayer-mediated interactions between integral membrane proteins, and large ...
arxiv +1 more source
The complement system consists of more than 30 plasma as well as cell surface proteins that together constitute a major arm of the immune system. The long-held belief is that most of the complement components are synthesized by hepatocytes in the liver ...
Berhane Ghebrehiwet
doaj +1 more source
Simulating the chromatin mediated phase separation of model proteins with multiple domains [PDF]
We perform simulations of a system containing simple model proteins and a polymer representing chromatin. We study the interplay between protein-protein and protein-chromatin interactions, and the resulting condensates which arise due to liquid-liquid phase separation, or a via a 'bridging-induced attraction' mechanism.
arxiv +1 more source
Preferential association of hepatitis C virus with CD19+ B cells is mediated by complement system [PDF]
Extrahepatic disease manifestations are common in chronic hepatitis C virus (HCV) infection. The mechanism of HCV-related lymphoproliferative disorders is not fully understood.
Alter, Harvey J.+7 more
core +1 more source