Results 61 to 70 of about 2,113,685 (392)

Factor H family proteins and human diseases [PDF]

open access: yes, 2008
Complement is a major defense system of innate immunity and aimed to destroy microbes. One of the central complement regulators is factor H, which belongs to a protein family that includes CFHL1 and five factor H-related (CFHR) proteins.
Abrera-Abeleda   +69 more
core   +1 more source

Complement and Cancer Immunity [PDF]

open access: yes, 2023
The complement system is considered as a crucial mediator of the innate immune mechanisms. its three activation pathways contribute to cellular homeostasis, and protect the host from exogenous pathogens and self-derived components.
and Uday Kishore   +3 more
core   +1 more source

Evaluation of nonionic and zwitterionic detergents as membrane protein solubilizers in two-dimensional electrophoresis [PDF]

open access: yesProteomics 3 (03/2003) 249-53, 2006
The solubilizing power of various nonionic and zwitterionic detergents as membrane protein solubilizers for two-dimensional electrophoresis was investigated. Human red blood cell ghosts and Arabidopsis thaliana leaf membrane proteins were used as model systems. Efficient detergents could be found in each class, i.e.
arxiv   +1 more source

Counterion-release entropy governs the inhibition of serum proteins by polyelectrolyte drugs [PDF]

open access: yesBiomacromolecules, 2018, 19 (2), pp 409-416, 2017
Dendritic polyelectrolytes constitute high potential drugs and carrier systems for biomedical purposes, still their biomolecular interaction modes, in particular those determining the binding affinity to proteins, have not been rationalized. We study the interaction of the drug candidate dendritic polyglycerol sulfate (dPGS) with serum proteins using ...
arxiv   +1 more source

Human complement control and complement evasion by pathogenic microbes - Tipping the balance [PDF]

open access: yes, 2013
Complement is a central homeotic system of mammals and represents the first defense line of innate immunity. The human complement system is aimed to maintain homeostasis by recognizing and removing damaged or modified self material, as well as infectious
Hallstroem, Teresia   +2 more
core   +1 more source

Hijacking Complement Regulatory Proteins for Bacterial Immune Evasion

open access: yesFrontiers in Microbiology, 2016
The human complement system plays an important role in the defense against invading pathogens, inflammation and homeostasis. Invading microbes, such as bacteria, directly activate the complement system resulting in the formation of chemoattractants and ...
Elise Sofie Hovingh   +4 more
doaj   +1 more source

Bilayer-thickness-mediated interactions between integral membrane proteins [PDF]

open access: yesPhys. Rev. E 93, 042410 (2016), 2016
Hydrophobic thickness mismatch between integral membrane proteins and the surrounding lipid bilayer can produce lipid bilayer thickness deformations. Experiment and theory have shown that protein-induced lipid bilayer thickness deformations can yield energetically favorable bilayer-mediated interactions between integral membrane proteins, and large ...
arxiv   +1 more source

Complement proteins in unexpected places: why we should be excited, not concerned! [version 1; peer review: 2 approved]

open access: yesF1000Research, 2020
The complement system consists of more than 30 plasma as well as cell surface proteins that together constitute a major arm of the immune system. The long-held belief is that most of the complement components are synthesized by hepatocytes in the liver ...
Berhane Ghebrehiwet
doaj   +1 more source

Simulating the chromatin mediated phase separation of model proteins with multiple domains [PDF]

open access: yes, 2021
We perform simulations of a system containing simple model proteins and a polymer representing chromatin. We study the interplay between protein-protein and protein-chromatin interactions, and the resulting condensates which arise due to liquid-liquid phase separation, or a via a 'bridging-induced attraction' mechanism.
arxiv   +1 more source

Preferential association of hepatitis C virus with CD19+ B cells is mediated by complement system [PDF]

open access: yes, 2016
Extrahepatic disease manifestations are common in chronic hepatitis C virus (HCV) infection. The mechanism of HCV-related lymphoproliferative disorders is not fully understood.
Alter, Harvey J.   +7 more
core   +1 more source

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