Results 91 to 100 of about 221,268 (260)

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

The conserved active site aspartate residue is required for the function of the chloroplast atypical kinase ABC1K1

Frontiers in Plant Science
IntroductionThe Arabidopsis abc1k1/pgr6 (Activity of BC1 complex/proton regulation 6) mutant is characterized by photosynthetic and conditional developmental phenotypes triggered by stressful red as well as high light.
Maud Turquand, Ana Rita Justo Da Silva, Thibaut Pralon, Fiamma Longoni, Felix Kessler, Joy Collombat   +5 more
doaj   +1 more source

Mobilizable Plasmids for Tunable Gene Expression in Francisella novicida

Frontiers in Cellular and Infection Microbiology, 2018
Francisella tularensis is the causative agent of the life-threatening disease tularemia. However, the molecular tools to study Francisella are limited.
Maj Brodmann, Rosalie Heilig, Petr Broz, Marek Basler   +3 more
doaj   +1 more source

Interlace Polynomials for Multimatroids and Delta-Matroids

, 2014
We provide a unified framework in which the interlace polynomial and several related graph polynomials are defined more generally for multimatroids and delta-matroids.
Aigner, Aigner, Arratia, Arratia, Arratia, Balister, Bollobás, Bouchet, Bouchet, Bouchet, Bouchet, Bouchet, Bouchet, Bouchet, Bouchet, Brijder, Brijder, Brijder, Courcelle, Ellis-Monaghan, Ellis-Monaghan, Ellis-Monaghan, Geelen, Geelen, Hendrik Jan Hoogeboom, Jaeger, Oxley, Robert Brijder, Rosenstiehl, Sokal, Traldi, Traldi, Tucker, Vertigan, Welsh, Zaslavsky   +35 more
core   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Nonsense mutation inside anthocyanidin synthase gene controls pigmentation in yellow raspberry (Rubus idaeus L.).

Frontiers in Plant Science, 2016
Yellow raspberry fruits have reduced anthocyanin contents and offer unique possibility to study the genetics of pigment biosynthesis in this important soft fruit.
Muhammad Zubair Rafique, Elisabete Carvalho, Ralf Stracke, Luisa Palmieri, Lorena Herrera, Antje Feller, Mickae Malnoy, Stefan Martens   +7 more
doaj   +1 more source

Isolation of Yeast DNA Replication Mutants in Permeabilized Cells [PDF]

, 1983
A random population of temperature-sensitive mutants was screened by assaying for defects in DNA synthesis in a permeabilized yeast DNA replication system. Twenty mutants defective in in vitro DNA synthesis have been isolated.
Campbell, Judith L., Huang, Nak-hui, Kuo, Chia-lam   +2 more
core  

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

Molecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan, Fenghua Tan, Jie Wu, Zhaoyang Zeng, Wenjia Guo, He Huang, Wei Xiong   +6 more
wiley   +1 more source

A gene-specific T2A-GAL4 library for Drosophila

eLife, 2018
We generated a library of ~1000 Drosophila stocks in which we inserted a construct in the intron of genes allowing expression of GAL4 under control of endogenous promoters while arresting transcription with a polyadenylation signal 3’ of the GAL4.
Pei-Tseng Lee, Jonathan Zirin, Oguz Kanca, Wen-Wen Lin, Karen L Schulze, David Li-Kroeger, Rong Tao, Colby Devereaux, Yanhui Hu, Verena Chung, Ying Fang, Yuchun He, Hongling Pan, Ming Ge, Zhongyuan Zuo, Benjamin E Housden, Stephanie E Mohr, Shinya Yamamoto, Robert W Levis, Allan C Spradling, Norbert Perrimon, Hugo J Bellen   +21 more
doaj   +1 more source

Every Hilbert space frame has a Naimark complement [PDF]

arXiv, 2011
Naimark complements for Hilbert space Parseval frames are one of the most fundamental and useful results in the field of frame theory. We will show that actually all Hilbert space frames have Naimark complements which possess all the usual properties for Naimark complements with one notable exception.
arxiv