Results 131 to 140 of about 616,916 (268)

Comparative BAC end sequence analysis of tomato and potato reveals overrepresentation of specific gene families in potato

, 2008
Background Tomato (Solanum lycopersicon) and potato (S. tuberosum) are two economically important crop species, the genomes of which are currently being sequenced.
Visser Richard GF, Giovannoni James J, Stiekema, W., Datema, E., Ham, R.C.H.J., van, Datema Erwin, Mueller, L.A., van Ham Roeland CHJ, Visser, R.G.F., Giovannoni, J.J., Buels Robert, Mueller Lukas A, Stiekema Willem J, Buels, R.   +13 more
core   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

The Capsaspora genome reveals a complex unicellular prehistory of animals

, 2013
To reconstruct the evolutionary origin of multicellular animals from their unicellular ancestors, the genome sequences of diverse unicellular relatives are essential. However, only the genome of the choanoflagellate Monosiga brevicollis has been reported
Chen, Zehua, Kerner, Pierre, Ruiz-Trillo, Iñaki, Vervoort, Michel, Sánchez-Pons, Núria, Russ, Carsten, Kramer, Eric, Carr, Martin, Roger, Andrew J., Suga, Hiroshi, Nusbaum, Chad, de Mendoza, Alex, Haas, Brian J., Lang, B. Franz, Manning, Gerard, Sebé-Pedrós, Arnau, Torruella, Guifré, Derelle, Romain, Brown, Matthew W.   +18 more
core   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

The complete chloroplast genome sequence of Lophophora diffusa

Mitochondrial DNA. Part B. Resources
Lophophora diffusa is a psychoactive plant of Cactaceae, morphologically similar to the mescaline-rich Lophophora williamsii but with a distinct alkaloid profile, posing significant challenges for law enforcement.
Teng Zhang, Nan Li, Zhe Cui, Yikai Wang, Xingliang Liu   +4 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Complete Genome Sequence of an Avian Metapneumovirus Subtype A Strain Isolated from Chicken () in Brazil.

, 2017
<p>We report here the complete genome sequence of an avian metapneumovirus (aMPV) isolated from a tracheal tissue sample of a commercial layer flock.
Lara B. Keid, Helena L. Ferreira, Ferreira, Helena L., Leonardo C. Caserta, Soares, Rodrigo M., Raphael M. Simão, Trícia M. F. de S. Oliveira, C.W. Arns, R.M. Soares, Steven Van Borm, L.S. Rizotto, J.C. Benassi, Oliveira, Tricia M. F. de S., L.C. Caserta, T.M.F. de S. Oliveira, H.L. Ferreira, L.B. Keid, Julia C. Benassi, Benassi, Julia C., Tereza C. Cardoso, Clarice W. Arns, G.P. Scagion, T.C. Cardoso, R.M. Simão, Simao, Raphael M., Keid, Lara B., Rodrigo M. Soares, Borm, Steven Van, Cardoso, Tereza C. [UNESP], Oliveira, Trícia M.F. de S., Rizotto, Lais S., Caserta, Leonardo C., Arns, Clarice W., S. Van Borm, Laís S. Rizotto, Scagion, Guilherme P., Guilherme P. Scagion, Van Borm, Steven, Cardoso, Tereza C.   +38 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source