Results 41 to 50 of about 1,693,695 (274)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Computational and Structural Biotechnology Journal, 2012 The combination of computational and directed evolution methods has proven a winning strategy for protein engineering. We refer to this approach as computer-aided protein directed evolution (CAPDE) and the review summarizes the recent developments in ...
Rajni Verma +2 more
doaj +3 more sources
Enhanced Engineering Teaching Through Computational Fluid Dynamics Software
Publicaciones e Investigación, 2011 The chemical reaction engineering course, one of the cornerstones of chemical and even environmental engineering programs, has been taught through introductory courses that do not necessarily have into account non-ideal reactors concepts, which are the ...
Victor Fernando Marulanda Cardona
doaj +1 more source
Heliyon, 2020 Fires are important responsible factors to cause catastrophic events in the process industries, whose consequences usually initiate domino effects. The artificial neural network has been shown to be one of the rapid methods to simulate processes in the ...
Hossein Mashhadimoslem +2 more
doaj +1 more source
Computer program for the design of toroidal transformers [PDF]
, 1973 Program relieves designer of most of the computational details, while he maintains control over most engineering decisions. Number of specifications that must be supplied by user allows for considerable flexibility and for exercise of engineering ...
Dayton, J. A., Jr.
core +1 more source
The Need, Benefits, and Demonstration of a Minimization Principle for Excited States
, 2015 It is shown that the standard methods of computing excited states in truncated spaces must yield wave functions that, beyond truncation, are in principle veered away from the exact, and a remedy is demonstrated via a presented functional, F$_n$, obeying ...
Bacalis, Naoum C.
core +1 more source
A Framework for Globally Optimizing Mixed-Integer Signomial Programs [PDF]
, 2013 Mixed-integer signomial optimization problems have broad applicability in engineering. Extending the Global Mixed-Integer Quadratic Optimizer, GloMIQO (Misener, Floudas in J. Glob. Optim., 2012. doi:10.1007/s10898-012-9874-7), this manuscript documents a
Floudas, CA, Misener, R
core +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
An efficient adaptive frequency sampling scheme for large-scale transient boundary element analysis
, 2015 The frequency-domain approach (FDA) to transient analysis of the boundary element method, although is appealing for engineering applications, is computationally expensive.
Rong, Junjie +3 more
core +2 more sources