Results 41 to 50 of about 3,522,805 (248)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Gaming addiction in adolescence (revisited) [PDF]
, 2014 Gaming addiction has become a topic of increasing research interest. Over the last 25 years, I have written many articles on adolescent video gaming for Education and Health as it is one of the research fields that is constantly evolving.
Griffiths, MD
core
Digital Game Addiction and Children
, 2023 This study examines the topic of digital game addiction and children. The study addresses the effects of digital games on children, addiction symptoms, and the impact of addiction on children’s social, academic, and psychological development.
Ersoy, Mustafa, Şahbaz, Ahmet Furkan
core +1 more source
Not Yet Game Over: A Reappraisal of Video Game Addiction
, 2018 The rapid expansion of video gaming in an internet-using society has brought on a renewed focus on the phenomenon of video game addiction. Despite this focus, there remains a crucial absence of consensus over the diagnostic criteria of video game ...
Jhee, Jiow Hee +2 more
core +2 more sources
Validation of the Game Addiction Scale among Adolescents [PDF]
مطالعات رسانههای نوینThe purpose of this research was to validate the online game addiction scale among students in Alborz city. The method of the current research was survey-descriptive. The research population included second-grade high school students in Alborz city.
Safdar Nabi Zadeh +4 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Addiction trends: Internet v casino gambling [PDF]
, 2006 Gambling addictions always result from an interaction and interplay between many factors including the person’s biological and/or genetic predisposition, their psychological constitution, their social environment and the nature of the activity itself ...
Griffiths, M
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source