Results 71 to 80 of about 50,609 (259)

‘Grand Theft Archive’: A Quantitative Analysis of the State of Computer Game Preservation

open access: yesInternational Journal of Digital Curation, 2008
Computer games, like other digital media, are extremely vulnerable to long-term loss, yet little work has been done to preserve them. As a result we are experiencing large-scale loss of the early years of gaming history.
Paul Gooding, Melissa Terras
doaj   +3 more sources

GAMING COMPUTER ENTHUSIASM AS A PREDICTOR OF ADOLESCENT BULLYING

open access: yesВестник Мининского университета, 2017
Introduction: In the era of intensive computerization of society, the computer becomes an integral part of the life of a modern teenager. The virtual world contributes to the formation and development of those forms of individuality, which are largely ...
A. V. Grishina, E. N. Volkova
doaj   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

open access: yesFEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli   +3 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

open access: yesAging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Reperfusion‐Dependent Outcomes After Endovascular Thrombectomy Stratified by NIHSS‐ASPECTS Clinical‐Core Mismatch

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This analysis evaluates the effect of successful reperfusion on functional outcomes after MT, stratified by admission National Institutes of Health Stroke Scale (NIHSS) and Alberta Stroke Program Early CT Score (ASPECTS) as surrogates for clinical‐core mismatch, using multicenter registry data.
Felix Schlicht   +53 more
wiley   +1 more source

Faderen som helt i computerspil

open access: yesAkademisk Kvarter, 2020
In the last few years, a new type of hero has emerged in computer games: the father, who has sole responsibility for a child. In this article, three action-adventure computer games are analyzed to explore how fatherhood extends the notion of masculinity ...
Thessa Jensen, Søren Hommel Østerlund
doaj   +1 more source

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket   +14 more
wiley   +1 more source

Computing equilibria of dynamic games

open access: yesProceedings of the Behavioral and Quantitative Game Theory: Conference on Future Directions, 2010
In two influential papers, Abreu, Pearce and Stacchetti (APS) (1986, 1990) developed set-valued dynamic programming techniques for solving certain classes of repeated game. They showed that, for these games, the set of sequential equilibrium payoffs can be computed as a fixed point of an operator analogous to the Bellman operator in dynamic programming.
Kenneth L. Judd, Sevin Yeltekin
openaire   +2 more sources

Anti‐CD19 CAR T Cells in Autoimmune Encephalitis: Inflammation Controlled, Neurodegeneration Unchecked?

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Just recently, successful chimeric antigen receptor (CAR) T cell therapy was reported in the first patient with refractory, anti‐diacylglycerol lipase alpha (DAGLA) antibody‐mediated autoimmune encephalitis, achieving partial clinical remission.
Dimitrios Mougiakakos   +9 more
wiley   +1 more source

Computer-based games in project management education: A review

open access: yesProject Leadership and Society
The work-readiness of Project Management (PM) graduates has been highly discussed topic during the last decade. Employers consistently seek graduates capable of thriving in the ever-changing, intricate, and challenging project environment. Computer-based
Roksana Jahan Tumpa   +3 more
doaj   +1 more source

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