Results 101 to 110 of about 122,411 (287)

Proximity‐Induced Transfer of a Mass Tag Enables Direct Profiling of Active Matrix Metalloproteases

Angewandte Chemie, EarlyView.
A proximity‐induced, mass‐encoded activity‐based protein profiling (ABPP) approach transfers a MALDI‐detectable α‐cyano‐4‐hydroxycinnamic acid (CHCA) tag directly to active proteases. This tag enables the direct, multiplexed, and quantitative detection of enzyme activity in complex proteomes without enrichment or purification.
Lomane Berthy, Ugo Pasco, Mylene Sejalon‐Cipolla, Pierrick Bruyat, Monika Kaminska, Carole Malgorn, Fabrice Beau, Manca Osolin, Metka Novak, Barbara Breznik, Dimitris Georgiadis, Isabelle Correia, Emeline Groult, Olivier Lequin, Sarah Bregant, Yves‐Marie Pers, Daniele Noel, Robert Thai, Gilles Subra, Sonia Cantel, Laurent Devel   +20 more
wiley   +2 more sources

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source

Design Rules for Controlling Connectivity, Topology, and Sorting Using Hydrogen‐Bonded Pairs and Aromatic Components in Palladium(II)‐Based Interlocked and Foldameric Systems

Angewandte Chemie, EarlyView.
We have established a set of design rules which combine Pd(II) metal coordination, complementary geometries, complementary interligand hydrogen bonding and π─π interactions for predictable self‐assembly of Pd(II)‐based species such as metallo‐foldamers, cyclic species a metallo‐interlocked clippane. The species persist in a combinatorial mixture due to
Jess L. Algar, Jordan N. Smith, Dan Preston   +2 more
wiley   +2 more sources

Abnormal neural responses to social exclusion in schizophrenia.

PLoS ONE, 2012
Social exclusion is an influential concept in politics, mental health and social psychology. Studies on healthy subjects have implicated the medial prefrontal cortex (mPFC), a region involved in emotional and social information processing, in neural ...
Victoria B Gradin, Gordon Waiter, Poornima Kumar, Catriona Stickle, Maarten Milders, Keith Matthews, Ian Reid, Jeremy Hall, J Douglas Steele   +8 more
doaj   +1 more source

Ethical Emissions Trading and the Law [PDF]

, 2006
The idea of permit trading in the United States can be traced as far back as the 1970s, but emissions trading has really only became a popular and exportable idea with the more recent demands that environmental protection acknowledge economic ...
Junker, Kirk W.
core  

Persistently Increased Expression of PKMzeta and Unbiased Gene Expression Profiles Identify Hippocampal Molecular Traces of a Long‐Term Active Place Avoidance Memory and “Shadow” Proteins

Advanced Science, EarlyView.
Protein complexes like KIBRA‐PKMζ are crucial for maintaining memories, forming month‐long protein traces in memory‐tagged neurons, but conventional RNA‐seq analysis fails to detect their transcript changes, leaving memory molecules undetected in the shadows of abundantly‐expressed genes.
Jiyeon Han, Alejandro Grau‐Perales, Rayna M. Harris, Edith Lesburguères, Hsin‐Yi Kao, Asit Pal, Juan Marcos Alarcon, Todd C. Sacktor, Stefano Martiniani, Hans A. Hofmann, André A. Fenton   +10 more
wiley   +1 more source

On a Coronal Blowout Jet: The First Observation of a Simultaneously Produced Bubble-like CME and a Jet-like CME in a Solar Event

, 2012
The coronal blowout jet is a peculiar category among various jet phenomena, of which the sheared base arch, often carrying a small filament, experiences a miniature version of blowout eruption that produces large-scale coronal mass ejection (CME).
Deng, Yuanyong, Liu, Yu, Shen, Yuandeng, Su, Jiangtao   +3 more
core   +1 more source

Spectroscopic Evidence of Edge‐Localized States in an Antiferromagnet Topological Insulator NdBi

Advanced Science, EarlyView.
Using spin‐polarized scanning tunneling microscopy (STM) in conjunction with quasiparticle interference, we successfully identify distinct signatures of the ferromagnetic and antiferromagnetic terminations in NdBi, a rare‐earth monopnictide exhibiting non‐trivial topology and magnetism. We demonstrate that step edges on ferromagnetic surfaces host well‐
Avior Almoalem, Rebecca Chan, Brinda Kuthanazhi, Juan Schmidt, Jose A. Moreno, Hermann Suderow, Paul Canfield, Taylor L. Hughes, Vidya Madhavan   +8 more
wiley   +1 more source

An Artificial Molecular Pump Powered by Light

Angewandte Chemie, EarlyView.
A minimal rotaxane‐based supramolecular system functions as a light‐powered molecular pump, capturing macrocycles from solution and concentrating them within an intramolecular compartment. Repeated azobenzene photoisomerization modulates the binding and kinetic barriers of threading and shuttling, generating a photon‐driven energy ratchet that sustains
Federico Nicoli, Chiara Taticchi, Stefano Corra, Marina Tranfić Bakić, Massimo Baroncini, Serena Silvi, Jessica Groppi, Alberto Credi   +7 more
wiley   +2 more sources

Development and Application of Concept Cartoons for Preschool Children

, 2014
[No abstract available]
Atasoy, Şengül, Zoroğlu, Muhammed Ali
openaire   +2 more sources