Results 61 to 70 of about 272,990 (263)
The Development of Students' Understanding of Science
Frontiers in Education, 2019 Children construct intuitive understandings of the physical world based on their everyday experiences. These intuitive understandings are organized in skeletal conceptual structures known as framework theories.
Stella Vosniadou
doaj +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Beyond two modes of thought: A quantum model of how three cognitive variables yield conceptual change. [PDF]
Front Psychol, 2022 Winslow M, Gabora L.
europepmc +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Ensaio Pesquisa em Educação em CiênciasResumo: Diante do desafio de consolidar e aprofundar as pesquisas no campo da educação em ciências, coloca-se a necessidade de se fazer um balanço crítico das pesquisas realizadas nos últimos vinte anos em torno do problema da "mudança conceitual".
Orlando Aguiar Jr.
doaj +1 more source
Long-Lasting Conceptual Change in Science Education: The Role of U-shaped Pattern of Argumentative Dialogue in Collaborative Argumentation. [PDF]
Sci Educ (Dordr), 2023 Li X, Li Y, Wang W.
europepmc +1 more source
Change in Conceptual Modeling and Systems Reconfiguration
CoRR, 2022 10 pages, 17 ...
openaire +3 more sources
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source