Results 71 to 80 of about 8,154,104 (309)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Altering misconceptions: how e-rebuttal texts on Newton’s laws reconstructs students’ mental models

Frontiers in Education
This study aims to explore how e-rebuttal texts on Newton’s laws can reconstruct students’ mental models by altering existing misconceptions. A mixed methods approach (quantitative and qualitative) was used in the research. Participants were 31 students (
Andi Suhandi, Achmad Samsudin, Nuzulira Janeusse Fratiwi, Nurdini Nurdini, Selly Feranie, Muhammad Guntur Purwanto, Suharto Linuwih, Bayram Coştu   +7 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

The Development of Students' Understanding of Science

Frontiers in Education, 2019
Children construct intuitive understandings of the physical world based on their everyday experiences. These intuitive understandings are organized in skeletal conceptual structures known as framework theories.
Stella Vosniadou
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Content Analysis for Recognizing Threads in Conceptual Change Research

, 2014
Since its origins - the publication of the milestone paper of Posner, Strike, Hewson and Gertzog in 1982 - conceptual change has been one of the main research issues in science education. The literature on conceptual change is wide and some researchers
BRANCHETTI L, TASQUIER G, BERNARDINI A
core  

When science needs conceptual change : what thermodynamics tells us about continuity of conceptualizations

, 2014
Classical thermodynamics is not an example upon which to base models of learning and conceptual change. Traditionally, thermodynamics serves as an example for a model of strong change.
Fuchs, Hans Ulrich
core   +2 more sources

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Beyond knowledge. Learner characteristics influencing conceptual change.

, 2013
We have painted a picture of the conceptual change process as complex, interactive, and at once cognitive, affective, and social. Key to understanding this multifaceted view is an examination of the role learner characteristics play in the interaction ...
Sinatra, G. M., MASON, LUCIA
core