Results 71 to 80 of about 273,614 (263)
Representing Earth Science Concepts through Slowmation: Influences on Conceptual Change
eTropic: electronic journal of studies in the tropics, 2015 It is well known that students arrive in science classrooms with pre-instructional ideas about science phenomena, and that often students’ ideas are not scientifically accurate representations of these phenomena.
Reece Mills +2 more
doaj +1 more source
A conceptual theory of state changes [PDF]
Semiotica, 1989 I will focus in this paper on what John Sowa calls the 'conceptual relations': In the formal theory there is only one primitive relation called LINK. All others are introduced by definitions. For a practical knowledge representation system, a reasonable number of basic relations should be provided for all the common relations that are used in ordinary ...
openaire +2 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
International Journal of Educational Psychology, 2018 Conceptual change can be a challenging process, particularly in science education where many of the concepts are complex, controversial, or counter-intuitive.
Louis S. Nadelson +4 more
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Ciência & Educação, 2003 Se hace un análisis crítico del tema cambio conceptual, a lo largo de un período de 20 años, a partir de una revisión parcial de la literatura y del referencial de la teoría del aprendizaje significativo.En dicho análisis se destaca la necesidad de ...
Marco Antonio Moreira +1 more
doaj +1 more source