Results 51 to 60 of about 272,990 (263)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Innovating higher education pedagogy: integrating RADEC learning model and virtual laboratory to promote pre-service elementary teachers’ conceptual change

Frontiers in Education
This study aimed to examine the efficacy of RADEC-based instructional materials, supplemented by a virtual laboratory, in promoting conceptual change among pre-service elementary teachers.
Henni Riyanti, Wahyu Sopandi, Dadi Mulyadi, Muslim   +3 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Beyond Evidence-Based Belief Formation: How Normative Ideas Have Constrained Conceptual Change Research

Frontline Learning Research, 2013
The cognitive sciences, including psychology and education, have their roots in antiquity. In the historically early disciplines like logic and philosophy, the purpose of inquiry was normative. Logic sought to formalize valid inferences, and the various
Stellan Ohlsson
doaj   +1 more source

Conceptualizing change in organizational cognition

International Journal of Organization Theory & Behavior, 2021
PurposeSecchi and Cowley (2016, 2018) propose a Radical approach to Organizational Cognition (ROC) as a way of studying cognitive processes in organizations. What distinguishes ROC from the established research on Organizational Cognition is that it remains faithful to radical, anti-representationalist principles of contemporary cognitive science ...
openaire   +2 more sources

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

Altering misconceptions: how e-rebuttal texts on Newton’s laws reconstructs students’ mental models

Frontiers in Education
This study aims to explore how e-rebuttal texts on Newton’s laws can reconstruct students’ mental models by altering existing misconceptions. A mixed methods approach (quantitative and qualitative) was used in the research. Participants were 31 students (
Andi Suhandi, Achmad Samsudin, Nuzulira Janeusse Fratiwi, Nurdini Nurdini, Selly Feranie, Muhammad Guntur Purwanto, Suharto Linuwih, Bayram Coştu   +7 more
doaj   +1 more source

Training As Exchange And Negotiation Of Knowledge: An Online And In Presence

Je-LKS: Journal of E-Learning and Knowledge Society, 2009
We propose a socio-constructivist conception of training, presenting a model of teaching-learning that we have used in traditional and online context at the University of Macerata.
Paola Nicolini, Tamara Lapucci
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source