Results 121 to 130 of about 622,206 (305)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Design, Implementation, and Evaulation of GIS-Based Learning Materials in an Introductory Geoscience Course [PDF]
, 2002 Little is known about how well GIS-based learning lives up to its potential for improving students' skills in problem solving, analysis, and spatial visualization.
Carla McAuliffe, Michelle Hall-Wallace
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
EMPIRICAL STUDY ON THE DETERMINANTS OF FDI INFLOWS TO ROMANIA [PDF]
Annals of the University of Oradea: Economic Science, 2016 The requirement was designed to not refer directly to the word ethics in order not to induce students prejudices when formulating their response. Conceptual maps developed by students were analyzed in terms of architecture and content, to identify the ...
Mariana Sehleanu
doaj
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
, 2017 El presente trabajo busca dar a entender una herramienta versátil para el trabajo de los docentes dentro de sus aulas. En nuestra práctica docente hemos aplicado esta estrategia de enseñanza aprendizaje con buenos resultados, por lo que el maestro que la aplique tendrá logros evidentes en sus estudiantes.
openaire +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Crude oil and its’ distillation: an experimental approach in High School using conceptual maps
Semina: Ciências Exatas e Tecnológicas, 2006 Conceptual maps are representations of ideas organized in the form of bidimensional diagrams. In the present work the theme of oil fractional distillation was explored, and the conceptual maps were elaborated both before and after the activities by 43 ...
Dionísio Borsato +3 more
doaj
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source