Results 121 to 130 of about 2,725,308 (288)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Grounded Theory Review: An International Journal, 2009 Grounded theory research in cross-language, cross-cultural context is associated with the challenges of linguistic sensitivity of conceptualization.
Svetlana Shklarov
doaj
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Grounded Theory Review: An International Journal, 2013 In the first chapter of this book, Glaser explains his purpose to help the researcher use the constant comparative method to discover and name patterns in the data, relate them to each other, generate a “conceptual hypothesis” (p.
Susan Stillman
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O konsekwencjach podmiocentryzmu w badaniach stylistycznych
Stylistyka, 2020 Polish stylistics of the last twenty years. She is concemed with the subject as the research object (subject in a text, discourse, genre) and as the research subject, which is the author of a scientific text in the stylistic field.
Bożena Witosz
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Ètičeskaâ refleksiâ v formirovanii nacionalʹnogo stilâ
Stylistyka, 2020 The article examines phenomena influencing ethical imperatives, mainly nalve ethics, upon the national style at the level o f the world linguistic picture in conceptualization, and at the level of word formation and grammatical categories.
Tatʹâna I. Surikova
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LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Explicit comprehension instruction : a review of research and a new conceptualization of instruction [PDF]
, 1988 Includes bibliographical references (p. 13-16)The work upon which this publication was based was supported in part by the Office of Educational Research and Improvement under cooperative agreement no.
Dole, Janice A., Pearson, P. David
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