Results 51 to 60 of about 139,918 (259)

The Effect of Concurrent Training on Serum Androgens Levels and Sexual Function in Menopausal Women

مراقبت پرستاری و مامایی ابن سینا, 2021
Background and Objective: Women's sexual function decreases during menopause, which in turn reduces their quality of life. Some studies have suggested that physical activity is associated with increased serum levels of androgens and improved sexual ...
Mohammad Parastesh, Zahra Mohseni, Esfandiar Khosravi Zadeh, Abbas Saremi   +3 more
doaj  

Using Molecular Biology to Maximize Concurrent Training [PDF]

Sports Medicine, 2014
Very few sports use only endurance or strength. Outside of running long distances on a flat surface and power-lifting, practically all sports require some combination of endurance and strength. Endurance and strength can be developed simultaneously to some degree.
openaire   +4 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Acute physiological responses and performance determinants in Hyrox© – a new running-focused high intensity functional fitness trend

Frontiers in Physiology
AimsHyrox© is a fitness modality combining 8 functional exercises with running in a comprehensive competition format. Within this first scientific study on Hyrox©, acute physiological responses, relative perceived exertion (RPE), and possible performance
Tom Brandt, Cindy Ebel, Christopher Lebahn, Annette Schmidt   +3 more
doaj   +1 more source

Effects of concurrent training and detraining on leptin and insulin concentrations in obese children [PDF]

فیزیولوژی ورزش و فعالیت بدنی, 2011
Aim: The aim of this study was to examine the effect of 12 weeks (3 days/week) concurrent training followed by 4 weeks detraining on leptin and insulin levels in obese boys.
سعید فاضلی فر, خسرو ابراهیم   +1 more
doaj   +1 more source

Efficiency of twice weekly concurrent training in trained elderly men

Experimental Gerontology, 2013
This study compared the effects of different weekly training frequencies on the cardiovascular and neuromuscular adaptations induced by concurrent training in previously trained elderly. After 20weeks of combined strength and endurance training, twenty-four healthy elderly men (65±4 years) were randomly placed into two frequency training groups ...
Rodrigo, Ferrari, Luiz Fernando Martins, Kruel, Eduardo Lusa, Cadore, Cristine Lima, Alberton, Mikel, Izquierdo, Matheus, Conceição, Ronei Silveira, Pinto, Régis, Radaelli, Eurico, Wilhelm, Martim, Bottaro, Jorge Pinto, Ribeiro, Daniel, Umpierre   +11 more
openaire   +2 more sources

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source