Results 91 to 100 of about 98,771 (295)

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

Mesenchymal Stromal Cell‐Mediated Intercellular Communication: Mapping the Interactome for Skeletal Muscle Homeostasis and Regeneration

Advanced Science, EarlyView.
Liu et al. define a systems‐level interactome of fibroadipogenic progenitor (FAP)‐mediated signaling in skeletal muscle by integrating single‐cell transcriptomics with FAP depletion‐based perturbation analysis. Functional interrogation using a conditioned media bioassay links predicted signaling to multicellular outcomes, establishing a framework to ...
Xingyu Liu, Edgar E. Perez Carbajal, Yih‐Chii Hwang, Sahil A. Mapkar, Benjamin W. Gilman, Sarah A. Bliss, Lam B. Tran, Kalgi T. Mehta, Jacob O. Banyasz, Ming Yu, Reynold R. Liu, Matthew N. Ly, Christapher S. Morrissey, Michael N. Wosczyna   +13 more
wiley   +1 more source

CATE meets ML -- The Conditional Average Treatment Effect and Machine Learning

, 2021
Tutorial paper, V2 contains fixes of minor ...
openaire   +3 more sources

Doubly Robust Direct Learning for Estimating Conditional Average Treatment Effect

, 2020
Inferring the heterogeneous treatment effect is a fundamental problem in the sciences and commercial applications. In this paper, we focus on estimating Conditional Average Treatment Effect (CATE), that is, the difference in the conditional mean outcome between treatments given covariates.
Meng, Haomiao, Qiao, Xingye
openaire   +2 more sources

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

Advanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang‐Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang   +16 more
wiley   +1 more source

Integrating Copula-Based Random Forest and Deep Learning Approaches for Analyzing Heterogeneous Treatment Effects in Survival Analysis

Mathematics
This paper presents deep learning models—specifically, Long Short-Term Memory (LSTM) networks and hybrid Convolutional Neural Network–LSTM (CNN-LSTM) with a Copula-Based Random Forest (CBRF) model to estimate Heterogeneous Treatment Effects (HTEs) in ...
Jong-Min Kim
doaj   +1 more source

rdhte: Conditional Average Treatment Effects in RD Designs

Understanding causal heterogeneous treatment effects based on pretreatment covariates is a crucial aspect of empirical work. Building on Calonico, Cattaneo, Farrell, Palomba, and Titiunik (2025), this article discusses the software package rdhte for estimation and inference of heterogeneous treatment effects in sharp regression discontinuity (RD ...
Calonico, Sebastian, Cattaneo, Matias D., Farrell, Max H., Palomba, Filippo, Titiunik, Rocio   +4 more
openaire   +2 more sources

Moving the Goalposts: Addressing Limited Overlap in Estimation of Average Treatment Effects by Changing the Estimand [PDF]

Estimation of average treatment effects under unconfoundedness or exogenous treatment assignment is often hampered by lack of overlap in the covariate distributions.
Richard K. Crump, Oscar A. Mitnik, V. Joseph Hotz, Guido W. Imbens   +3 more
core  

Estimation of conditional average treatment effects [PDF]

, 2014
University of Minnesota Ph.D. dissertation. July 2014. Advisor: Yuhong Yang. Major: Statistics. 1 computer file (PDF); viii, 128 pages, appendices A-B.Researchers often believe that a treatment's effect on a response may be heterogeneous with respect to ...
Rolling, Craig Anthony
core  

Estimating average partial effects under conditional moment independence assumptions [PDF]

, 2004
I show how to identify and estimate the average partial effect of explanatory variables in a model where unobserved heterogeneity interacts with the explanatory variables and may be unconditionally correlated with the explanatory variables.
Wooldridge, Jeffrey M., Jeffrey M. Wooldridge   +1 more
core   +1 more source