Results 81 to 90 of about 18,931,441 (264)

Implications of acute change in estimated Glomerular Filtration Rate (eGFR) for the effect of sodium-glucose cotransporter-2 inhibitors (SGLT-2i) on long-term endpoints.

PLoS ONE
In randomized trials, the primary analysis often estimates the average treatment effect on a clinical endpoint. Some treatments also lead to early changes in a biomarker that is prognostic for the clinical endpoint, prompting investigators to explore how
Ransmond O Berchie, Lesley A Inker, Hiddo J L Heerspink, Ben Haaland, Tom Greene   +4 more
doaj   +1 more source

Parkinson Disease Subtype Stability and Eventual Convergence

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Previous research identified distinct Parkinson disease (PD) clinical subtypes of “Motor Only,” “Psychiatric & Motor,” and “Cognitive & Motor” based on comprehensive, multidomain classification. Whether these subtypes reflect distinct trajectories or progressive disease stages remains unknown.
Laura M. Rosok, Christina N. Lessov‐Schlaggar, Abdulmunaim M. Eid, Erin R. Foster, Baijayanta Maiti, Hailee Domash, Helen Hwang, Richard J. Perrin, Paul T. Kotzbauer, Joel S. Perlmutter, Meghan C. Campbell   +10 more
wiley   +1 more source

Early metoprolol use in ICU patients with congestive heart failure is associated with increased 30-day mortality: a causal machine learning study

Frontiers in Pharmacology
BackgroundThe risk-benefit balance of early metoprolol administration in critically ill patients with congestive heart failure (CHF) admitted to the intensive care unit (ICU) remains controversial.
Yunzhu Chen, Tianyou Li
doaj   +1 more source

2D score-based estimation of heterogeneous treatment effects

Journal of Causal Inference, 2023
Statisticians show growing interest in estimating and analyzing heterogeneity in causal effects in observational studies. However, there usually exists a trade-off between accuracy and interpretability for developing a desirable estimator for treatment ...
Ye Steven Siwei, Chen Yanzhen, Padilla Oscar Hernan Madrid   +2 more
doaj   +1 more source

Automatic Lesion Morphometrics Reliably Predict Sensorimotor Recovery After Spinal Cord Injury: A Longitudinal, Multicenter Neuroimaging Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate automatic magnetic resonance imaging (MRI)‐derived lesion morphometrics against manual measurements and their prognostic value for characterizing distinct acute to chronic neurological recovery trajectories after spinal cord injury (SCI). Methods We studied a retrospective, multicenter cohort of cervical and thoracolumbar
Dario Pfyffer, Jan Valošek, Lynn Farner, Enamundram Naga Karthik, Gergely David, Norbert Weidner, Rainer Abel, Doris Maier, Armin Curt, Margret Hund‐Georgiadis, Mirko Aach, Michael Baumberger, Julien Cohen‐Adad, Patrick Freund, the Nogo Inhibition in Spinal Cord Injury Study Group, Rainer Abel, Kerstin Rehahn, Mirko Aach, Klaus Röhl, Norbert Weidner, Marion Saur, Nikolaus Weiskopf, Doris Maier, Andreas Badke, Margret Hund‐Georgiadis, Michael Baumberger, Armin Curt, Jesus Benito‐Penalva, Jiri Kriz   +28 more
wiley   +1 more source

Estimating average partial effects under conditional moment independence assumptions [PDF]

, 2004
I show how to identify and estimate the average partial effect of explanatory variables in a model where unobserved heterogeneity interacts with the explanatory variables and may be unconditionally correlated with the explanatory variables.
Wooldridge, Jeffrey M., Jeffrey M. Wooldridge   +1 more
core   +1 more source

Estimating treatment effects from non-overlapping cohorts with application to antimicrobial resistance

BMC Medical Research Methodology
Background The positivity assumption, also known as overlap, is one of the key assumptions for causal inference. However, in certain observational studies it does not hold.
Avi Baraz, Daniel Nevo, Amos Cahan, Tal Brosh-Nissimov, Michal Chowers, Uri Obolski   +5 more
doaj   +1 more source

SpatialMed-CF: A Unified Spatial Mediation Causal Forest Framework for Evaluating Heterogeneous Effects of Urban Greening Interventions

Atmosphere
Urban greening interventions are widely implemented to mitigate urban heat islands, but rigorous causal evaluation is hindered by three challenges: interventions are not randomly assigned (selection bias), treatment effects are heterogeneous across urban
Zhiyu Jia, Yanchuan Yang, Ze Wang, Xin Ming, Shijun Ge, Xu Han   +5 more
doaj   +1 more source

Serostatus‐Specific Prognostic Profiles and Phenotype‐Dependent Therapeutic Windows in Autoimmune Encephalitis: A Multicenter Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background While autoimmune encephalitis (AE) outcomes vary, serostatus‐specific prognostic determinants and institutional clustering effects remain poorly characterized. We aimed to delineate the distinct prognostic architecture of AE, identifying serostatus‐specific risk factors and potential therapeutic windows.
Xiaohong Tang, Jingxian Wang, Kaixin Zhu, Zhen Zhang, Liao Wu, Wei Wang, Chang Li, Qingyun Li, Hao Li, Jinghua Chen, Zhangxu Lian, Bin Liu, Tengfei Liu, Chunmei Wen, Nuan Wang, Sen Qun, Lishun Xiao, Qingwei Lai   +17 more
wiley   +1 more source

A Copula-Driven CNN-LSTM Framework for Estimating Heterogeneous Treatment Effects in Multivariate Outcomes

Mathematics
Estimating heterogeneous treatment effects (HTEs) across multiple correlated outcomes poses significant challenges due to complex dependency structures and diverse data types.
Jong-Min Kim
doaj   +1 more source