Results 131 to 140 of about 538,273 (301)

On the Possibility of Medium-Energy Compact X-ray Free-Electron Laser

, 2012
The problem of X-ray Free-Electron Laser operating on self-amplified spontaneous emission in irregular microundulator is considered. The case when the spectrum width of spontaneous radiation is conditioned by the spatial distribution of sources creating ...
Gevorgian, Lekdar, Vardanyan, Valeri
core  

Analytical results for a conditional phase shift between single-photon pulses in a nonlocal nonlinear medium

, 2017
It has been suggested that second-order nonlinearities could be used for quantum logic at the single-photon level. Specifically, successive two-photon processes in principle could accomplish the phase shift (conditioned on the presence of two photons in ...
Gea-Banacloche, Julio, Viswanathan, Balakrishnan   +1 more
core   +1 more source

L929 CONDITIONED MEDIUM (LCM) v1

Macrophage colony stimulating factors (M-CSF) are secreted by L929 cells (ATCC) and promote bone marrow progenitors to differentiate into a heterogeneous population of bone marrow derived macrophages (BMDM) expressing various myeloid surface markers (CD11b, F4/80, BM8, CD31, CD68, CD11c, Ly6C, GR1 ...
openaire   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Investigating the Effect of Co-culturing Human Adipose-Derived Stem Cells on Retinal Cells Survival and Migration in Vitro Environment

مجله دانشکده پزشکی اصفهان, 2017
Background: Human adipose-derived stem cells (hADSCs) are population of cells isolated from adipose tissue. hADSCs have ability to differentiate along multiple cell lineages and secret verity of growth factors, which affect the neighboring cells ...
Leila Naseri, Noushin Amirpour, Hamid Bahramian, Hossein Salehi   +3 more
doaj  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Serum-free spontaneously immortalized bovine oviduct epithelial cell conditioned medium promotes the early development of bovine in vitro fertilized embryos

The Journal of Reproduction and Development
Embryonic transfer of bovine blastocysts produced using in vitro fertilization (IVF) is widely used, although the challenge of compromised conception rates remains.
Norikazu MIYASHITA, Satoshi AKAGI, Tamas SOMFAI, Yuji HIRAO   +3 more
doaj   +1 more source

Gain Modulation by Corticostriatal and Thalamostriatal Input Signals during Reward-Conditioned Behavior. [PDF]

, 2019
The cortex and thalamus send excitatory projections to the striatum, but little is known about how these inputs, either individually or collectively, regulate striatal dynamics during behavior.
Bakhurin, Konstantin I, Cepeda, Carlos, Chong, Natalie C, Claar, Leslie D, Holley, Sandra M, Lee, Kwang, Levine, Michael S, Masmanidis, Sotiris C   +7 more
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Conditioned serum-free culture medium accomplishes adhesion and proliferation of bovine myogenic cells on uncoated dishes

npj Science of Food
To establish a sustainable cultured meat technology, a low-cost culture medium must be developed without expensive biological materials such as serum and coating substances.
Takashi Morikura, Katsuhisa Sakaguchi, Ryu-ichiro Tanaka, Azumi Yoshida, Hironobu Takahashi, Kiyotaka Iwasaki, Tatsuya Shimizu   +6 more
doaj   +1 more source