Results 1 to 10 of about 22,252 (260)

Impact of Exercise on Tramadol-Conditioned Place Preference [PDF]

Brain Sciences
Background: Tramadol (TRA) is an opioid that is used to manage moderate to severe pain. Long-term use of TRA can lead to the development of opioid use disorder.
Haneen Amawi, Alaa M. Hammad, Aseel Abdullah Ibrahim, Nosyba Alsbih, Frank Scott Hall, Fawaz Alasmari, Bahaa Al-Trad   +6 more
doaj   +2 more sources

Modulating morphine-induced conditioned place preference: The role of diclofenac sodium [PDF]

Toxicology Reports
Morphine is known to induce strong reward-related behaviors, contributing to its high addiction potential. Non-steroidal anti-inflammatory drugs (NSAIDs), such as diclofenac sodium, have been suggested to modulate neuroinflammatory pathways involved in ...
Haneen Amawi, Rawan Alhazaimeh, Alaa M. Hammad, Aseel O. Rataan, Sahar Alsheyab, Tayma Maklouf, Bahaa Al-Trad, Karem H. Alzoubi   +7 more
doaj   +2 more sources

Running Reward Conditioned Place Preference Task

Bio-Protocol, 2016
The conditioned place preference (CPP) test is a standard pre-clinical behavioral tool used to study the motivational effects of drugs and non-drug treatments in experimental animals.
Maria Fernandes, Stephanie Fulton
doaj   +2 more sources

Khat-induced conditioned place preference, extinction, and reinstatement in female mice [PDF]

IBRO Neuroscience Reports
Khat (Catha edulis Forsk), the natural source of cathinone and other psychoactive agents, is chewed by millions of persons in eastern Africa and the Arabian Peninsula for its psychostimulant effect.
Caroline K. Murithi, Jacques M. Kabaru, Nilesh B. Patel   +2 more
doaj   +2 more sources

Non-invasive temporal interference brain stimulation reduces preference on morphine-induced conditioned place preference in rats [PDF]

Scientific Reports
Long-term use of opioid drugs such as morphine can induce addiction in the central nervous system through dysregulation of the reward system of the brain.
Zohre Mojiri, Ehsan Rouhani, Amir Akhavan, Zahra Jokar, Hojjatallah Alaei   +4 more
doaj   +2 more sources

Examining Sex Differences in Conditioned Place Preference or Aversion to Methamphetamine in Adolescent and Adult Mice

Frontiers in Pharmacology, 2021
Adolescence marks a particularly vulnerable period to developing substance use disorders. Human and rodent studies suggest that hypersensitivity to reward may contribute towards such vulnerability when adolescents are exposed to casual drug use ...
Ellen R. Cullity, Ellen R. Cullity, Alexandre A. Guerin, Alexandre A. Guerin, Christina J. Perry, Christina J. Perry, Jee Hyun Kim, Jee Hyun Kim, Jee Hyun Kim   +8 more
doaj   +1 more source

An ethogram analysis of cutaneous thermal pain sensitivity and oxycodone reward-related behaviors in rats

Scientific Reports, 2023
Inter-relationships between pain sensitivity, drug reward, and drug misuse are of considerable interest given that many analgesics exhibit misuse potential.
Ariana C. Brice-Tutt, Darrice S. Montgomery, Cassidy M. Kramer, Peter M. Novotny, Wendi L. Malphurs, Abhisheak Sharma, Robert. M. Caudle, Adriaan W. Bruijnzeel, Barry Setlow, John K. Neubert, Niall P. Murphy   +10 more
doaj   +1 more source

Quetiapine-Induced Place Preference in Mice: Possible Dopaminergic Pathway

Pharmaceuticals, 2021
Quetiapine, an atypical antipsychotic, is effective in the management of schizophrenia, depression, and anxiety. Although quetiapine overdosage and misuse have been reported, its abuse potential has not been investigated in animals.
Yusuf S. Althobaiti
doaj   +1 more source

Opposing Spatially Segregated Function of Endogenous GDNF-RET Signaling in Cocaine Addiction

Biomolecules, 2023
Cocaine addiction is a serious condition with potentially lethal complications and no current pharmacological approaches towards treatment. Perturbations of the mesolimbic dopamine system are crucial to the establishment of cocaine-induced conditioned ...
Daniel R. Garton, Giorgio Turconi, Vilma Iivanainen, Jaan-Olle Andressoo   +3 more
doaj   +1 more source

Spermidine prevents the reinstatement of alcohol conditioned place preference

Addiction Neuroscience, 2023
This study investigates whether spermidine (SPD), an endogenous polyamine, alters extinction and reinstatement of alcohol-induced conditioned place preference (CPP) in adult female Swiss mice.
Avner Almeida Silva, Gabrielle de Morais Henriques, Victor Nascimento-Rocha, Behaim Correia Dias-Júnior, Alexia dos Anjos Santos, Alexandre Justo Oliveira Lima, Eduardo Ary Villela Marinho, Maribel Antonello Rubin, Carlos Fernando Mello   +8 more
doaj   +1 more source