Results 221 to 230 of about 22,902 (258)

Clozapine attenuates cocaine conditioned place preference

Life Sciences, 1994
Clozapine, an atypical neuroleptic, has dopamine and serotonin antagonist actions that suggest its potential as a cocaine abuse pharmacotherapy. Yet, self-administration and discriminative stimulus studies in animals have reported both an enhancement and a partial blockade of cocaine's behavioral effects with clozapine.
T A, Kosten, E J, Nestler
openaire   +2 more sources

Dimenhydrinate produces a conditioned place preference in rats

Pharmacology Biochemistry and Behavior, 2003
Dimenhydrinate (DMH; trade names Gravol and Dramamine) is a compound of diphenhydramine (DP) and 8-chlorotheophylline in equimolar ratios. DMH has been reported to be abused by humans for its euphoric and hallucinogenic properties but few studies have evaluated its reinforcing effects in animals. To evaluate the hypothesis that DMH and its constituents
Alison G, Halpert, Mary C, Olmstead, Richard J, Beninger   +2 more
openaire   +2 more sources

Nicotine-induced conditioned place preferences in humans

Behavioural Brain Research
This study investigated whether a conditioned place preference (CPP) could be established for a virtual reality (VR) room paired with nicotine. Forty-four undergraduates with nicotine use completed a 3-day, within-subjects protocol. In session 1, participants were randomly assigned to receive either a 4 mg nicotine or placebo lozenge.
Skyler M. Sklenarik, Christopher N. Burrows, Robert S. Astur   +2 more
openaire   +2 more sources

Clonidine produces a conditioned place preference in rats

Psychopharmacology, 1985
The possibility that the alpha-adrenergic agonist clonidine can act as a reinforcing agent was investigated using the conditioned place preference paradigm. Using two different variants of this method we were able to demonstrate reinforcing properties of clonidine at doses of 200 and 400 micrograms/kg.
K E, Asin, D, Wirtshafter
openaire   +2 more sources

Pipradrol conditioned place preference is blocked by SCH23390

Pharmacology Biochemistry and Behavior, 1992
We investigated the effect of the selective D1 dopamine antagonist, SCH23390, on the establishment of a pipradrol-conditioned place preference (CPP). Among various doses of pipradrol (6.25-75.0 mg/kg, SC), a CPP was established at 25.0 mg/kg. SCH23390 (0.16 mg/kg, IP) blocked the establishment of a CPP by this dose of pipradrol.
N M, White, N, Hiroi
openaire   +2 more sources

Pentylenetetrazole can induce a conditioned place preference

Pharmacology Biochemistry and Behavior, 1991
Thirty-two male Sprague-Dawley rats were randomly selected into 4 groups (n = 8/group) and conditioned in a standard place preference task. The groups differed in the dose of pentylenetetrazole (PTZ) administered prior to conditioning trials. With respect to the three treatment groups, placement into the, initially, nonpreferred side of the CPP ...
D V, Gauvin, K N, Dormer, F A, Holloway
openaire   +2 more sources

Social influences on morphine conditioned place preference

Behavioural Pharmacology, 1997
Social defeat in dominant male rats has previously been shown to result in a loss of rank, together with decreased consumption of a palatable sucrose solution, suggestive of a decrease in hedonic tone. The present study further investigated the effect of defeat on hedonic capacity using the conditioned place preference paradigm.
COVENTRY T., D'AQUILA, Paolo Stefano, BRAIN P., WILLNER P.   +3 more
openaire   +3 more sources

Neuronal mechanism of phencyclidine-induced place aversion and preference in the conditioned place preference task

Methods and Findings in Experimental and Clinical Pharmacology, 1998
Place conditioning paradigms are widely used for determining the motivational properties of drugs. Phencyclidine (PCP) has been a common drug of abuse during the past two decades and has a rewarding effect in animals. However, PCP produces place aversion in the conditioned place preference (CPP) task in animals.
Y, Noda, T, Nabeshima
openaire   +2 more sources

Conditioned Place Preference (CPP) in Rats: From Conditioning to Reinstatement Test

2020
Opioid addiction in humans is a chronically relapsing disorder characterized by discontinuous periods of drug use and abstinence resulting in dependence. With time, the probability of falling into renewed drug consumption becomes particularly high and constitutes a considerable problem in the management of opioid addicts. Opioid addiction represents an
Scherma M., Fattore L., Fratta W., Fadda P.   +3 more
openaire   +4 more sources

Female rats develop conditioned place preferences for sex at their preferred interval

Hormones and Behavior, 2003
Female rats engage in approach and avoidance behaviors directed toward the male to "pace" the rate of copulation. These pacing behaviors result in a pattern of vaginocervical stimulation that triggers a neuroendocrine reflex that is important for pregnancy to result from insemination. Each female rat has a preferred pacing interval, and females develop
William J, Jenkins, Jill B, Becker
openaire   +2 more sources