Results 21 to 30 of about 22,252 (260)

Ibogaine Blocks Cue- and Drug-Induced Reinstatement of Conditioned Place Preference to Ethanol in Male Mice

Frontiers in Pharmacology, 2021
Ibogaine is a psychedelic extracted from the plant Tabernanthe iboga Baill. (Apocynaceae), natural from Africa, and has been proposed as a potential treatment for substance use disorders.
Gabrielle M. Henriques, Alexia Anjos-Santos, Alexia Anjos-Santos, Isa R. S. Rodrigues, Victor Nascimento-Rocha, Henrique S. Reis, Matheus Libarino-Santos, Thaísa Barros-Santos, Thais S. Yokoyama, Natalia B. Bertagna, Cristiane A. Favoretto, Célia R. G. Moraes, Fábio C. Cruz, Paulo C. R. Barbosa, Eduardo A. V. Marinho, Alexandre J. Oliveira-Lima, Laís F. Berro, Laís F. Berro   +17 more
doaj   +1 more source

Novel Putative Positive Modulators of α4β2 nAChRs Potentiate Nicotine Reward-Related Behavior

Molecules, 2021
The popular tobacco and e-cigarette chemical flavorant (−)-menthol acts as a nonselective, noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs), and contributes to multiple physiological effects that exacerbates nicotine addiction ...
Skylar Y. Cooper, Austin T. Akers, Velvet Blair Journigan, Brandon J. Henderson   +3 more
doaj   +1 more source

Activation of Astrocytic μ-Opioid Receptor Causes Conditioned Place Preference

Cell Reports, 2019
Summary: The underlying mechanisms of how positive emotional valence (e.g., pleasure) causes preference of an associated context is poorly understood. Here, we show that activation of astrocytic μ-opioid receptor (MOR) drives conditioned place preference
Min-Ho Nam, Kyung-Seok Han, Jaekwang Lee, Woojin Won, Wuhyun Koh, Jin Young Bae, Junsung Woo, Jayoung Kim, Elliot Kwong, Tae-Yong Choi, Heejung Chun, Seung Eun Lee, Sang-Bum Kim, Ki Duk Park, Se-Young Choi, Yong Chul Bae, C. Justin Lee   +16 more
doaj   +1 more source

Parvalbumin Interneurons Determine Emotional Valence Through Modulating Accumbal Output Pathways

Frontiers in Behavioral Neuroscience, 2019
Parvalbumin (PV) expressing GABAergic interneurons provide large source of GABA to spiny projection neurons (SPNs) in the striatum. However, the roles of PV+ interneurons in the regulation of SPNs in the ventral striatum and emotional states are largely ...
Xi Chen, Zhiyuan Liu, Chaonan Ma, Lan Ma, Xing Liu   +4 more
doaj   +1 more source

Conditioned place preference of kisspeptin-10

Reviews on Clinical Pharmacology and Drug Therapy, 2021
INTRODUCTION: Kisspeptins (KISS), a group of brain neuropeptides are involved in sexual behavior. KISS activate the hypothalamic neurons that synthesize gonadotropin releasing hormone. KISS was also detected in the limbic system. Earlier, we showed the activation of sexual motivation after the administration of kisspeptin-10 without increasing the ...
Ilia Yu. Tissen, Polina A. Chepik, Andrei A. Lebedev, Leila A. Magarramova, Eugenii R. Bychkov, Petr D. Shabanov   +5 more
openaire   +1 more source

Cocaine-Induced Reinstatement of a Conditioned Place Preference in Developing Rats: Involvement of the D2 Receptor

Brain Sciences, 2012
Reinstatement of conditioned place preferences have been used to investigate physiological mechanisms mediating drug-seeking behavior in adolescent and adult rodents; however, it is still unclear how psychostimulant exposure during adolescence affects ...
Kimberly A. Badanich, Cheryl L. Kirstein
doaj   +1 more source

Corticosterone fails to produce conditioned place preference or conditioned place aversion in rats [PDF]

Behavioural Brain Research, 2007
In some rats, the hormone corticosterone is reinforcing. High novelty-seeking rats (high responders, HR) self-administered corticosterone at a much higher rate than low novelty-seeking rats (low responders, LR) do [Piazza PV, Deroche V, Deminiere JM, Maccari S, Le Moal M, Simon H, Corticosterone in the range of stress-induced levels possesses ...
David, Dietz, Hui, Wang, Mohamed, Kabbaj
openaire   +2 more sources

Blocking TRPV1 in nucleus accumbens inhibits persistent morphine conditioned place preference expression in rats.

PLoS ONE, 2014
The function of TRPV1 (transient receptor potential vanilloid subfamily, member 1) in the central nervous system is gradually elucidated. It has been recently proved to be expressed in nucleus accumbens (NAc), a region playing an essential role in ...
Li-Jun Heng, Bo Huang, Heng Guo, Lian-Ting Ma, Wei-Xin Yuan, Jian Song, Peng Wang, Guo-Zheng Xu, Guo-Dong Gao   +8 more
doaj   +1 more source

Magnesium-induced conditioned place preference in mice

Pharmacology Biochemistry and Behavior, 1990
A conditioned place preference procedure was used in mice to test the hypothesis that magnesium possesses reinforcing properties. Mice were conditioned to the nonpreferred end of a three-compartment straight shuttle box with MgCl2 injections alternating with saline injections on the preferred end. Dose of MgCl2 was varied (0, 15, 30, 125 mg/kg) as well
S I, Lawley, K M, Kantak
openaire   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source