Results 51 to 60 of about 4,305,638 (286)
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Advanced Biomedical Research, 2014 Background: Some investigators indicated the effect of electrical or chemical stimulation on different parts of the brain and its effect on animal′s behaviors.
Maryam Radahmadi +4 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
, 2013 Recent studies have indicated that the insula underlies affective learning. Although affective learning is well-established in the development of opiate addiction, the role of insula in this context remains unclear.
Zhu, Ning +5 more
core +1 more source
Intravenous cocaine priming reinstates cocaine-induced conditioned place preference
Psicológica, 2007 Grupos independientes de ratas fueron sometidos a un procedimiento de preferencia al lugar condicionada (PLC) involucrando emparejamientos alternados de ambientes distintivos con inyecciones intravenosas (IV) de cocaína (.75 mg/kg) o de ...
Anthony L. Riley +3 more
doaj
Behavior and hippocampal Epac signaling to nicotine CPP in mice
Translational Neuroscience, 2019 Tobacco use is a major challenge to public health in the United States and across the world. Many studies have demonstrated that adult men and women differ in their responses to tobacco smoking, however neurobiological studies about the effect of smoking
Liu Jing +7 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Conditioned place preference and spatial memory: contributions towards thalamus and memory [PDF]
, 2006 Conventional theories of diencephalic amnesia have focused on a single thalamic region as a critical factor in the origins of anterograde amnesia. A more contemporary view is that different thalamic regions might contribute in unique ways to normal ...
Adams, Melissa Jean
core +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Absence of methamphetamine‐induced conditioned place preference in weaver mutant mice
Neuropsychopharmacology Reports, 2020 Aims G protein‐activated inwardly rectifying potassium (GIRK) channels are related to rewarding effects of addictive drugs. The GIRK2 subunit is thought to play key roles in the reward system.
Yuiko Ikekubo +3 more
doaj +1 more source