Results 61 to 70 of about 197,171 (310)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Cocaine-induced structural plasticity in frontal cortex correlates with conditioned place preference. [PDF]

, 2013
Contextual cues associated with previous drug exposure can trigger drug craving and seeking, and form a substantial obstacle in substance use recovery.
Athilingam, Jegath, Muñoz-Cuevas, Francisco Javier, Piscopo, Denise, Wilbrecht, Linda   +3 more
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Cannabidiol Mitigates Opioid Reward On Conditioned Place Preference In Mice [PDF]

, 2017
This study sought to determine whether the cannabis constituent, cannabidiol (CBD), is able to attenuate morphine reward in the conditioned place preference (CPP) paradigm.
Markos, James Roland
core   +1 more source

Post-retrieval propranolol treatment does not modulate reconsolidation or extinction of ethanol-induced conditioned place preference [PDF]

, 2012
The reconsolidation hypothesis posits that established emotional memories, when reactivated, become labile and susceptible to disruption. Post-retrieval injection of propranolol (PRO), a nonspecific ß-adrenergic receptor antagonist, impairs subsequent ...
Cunningham, Christopher L., Font Hurtado, Laura   +1 more
core   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Hippocampal and amygdalar increased BDNF expression in the extinction of opioid-induced place preference

IBRO Neuroscience Reports, 2022
The opioid crisis was exacerbated during the COVID-19 pandemic in the United States with alarming statistics about overdose-related deaths. Current treatment options, such as medication assisted treatments, have been unable to prevent relapse in many ...
Mario E. Lloret-Torres, Roxsana N. Ayala-Pagán, Freddyson J. Martínez-Rivera, Pedro Bonilla-Rullán, Jennifer L. Barreto-Estrada   +4 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Intravenous cocaine priming reinstates cocaine-induced conditioned place preference

Psicológica, 2007
Grupos independientes de ratas fueron sometidos a un procedimiento de preferencia al lugar condicionada (PLC) involucrando emparejamientos alternados de ambientes distintivos con inyecciones intravenosas (IV) de cocaína (.75 mg/kg) o de ...
Anthony L. Riley, Peter G. Roma, Kevin B. Freeman, Andrés S. Lombas   +3 more
doaj  

Periadolescent oral manganese exposure affects conditioned place preference by cocaine and conditioned place aversion by lithium chloride in rats [PDF]

, 2013
Due to the character of the original source materials and the nature of batch digitization, quality control issues may be present in this document. Please report any quality issues you encounter to digital@library.tamu.edu, referencing the URI of the ...
Lee, Samuel Ming Hin
core   +1 more source