Results 1 to 10 of about 550,405 (246)

Flecainide induces a sustained countercurrent dependent effect on RyR2 in permeabilized WT ventricular myocytes but not in intact cells

Frontiers in Pharmacology, 2023
Background and purpose: While flecainide is now an accepted treatment for arrhythmias associated with catecholaminergic polymorphic ventricular tachycardia (CPVT), its mechanism of action remains controversial.
Emma J. Steer, Zhaokang Yang, Moza M. Al-Owais, Hannah M. Kirton, Edward White, Derek S. Steele   +5 more
doaj   +1 more source

Preoperative Evaluation through Dermoscopy and Reflectance Confocal Microscopy of the Lateral Excision Margins for Primary Basal Cell Carcinoma

Diagnostics, 2021
Complete removal of malignant skin lesions with minimal impact on the aesthetic and functional aspects is the ideal of every dermatologic surgeon. Incomplete surgical excisions and tumor recurrences of basal cell carcinomas (BCC) commonly occur due to ...
Mihai Lupu, Vlad Mihai Voiculescu, Ana Caruntu, Tiberiu Tebeica, Constantin Caruntu   +4 more
doaj   +1 more source

Feasibility and Implementation of Ex Vivo Fluorescence Confocal Microscopy for Diagnosis of Oral Leukoplakia: Preliminary Study

Diagnostics, 2021
Background: Oral leukoplakia is a potentially malignant lesion with a clinical impression similar to different benign and malignant lesions. Ex vivo fluorescence confocal microscopy is a developing approach for a rapid “chairside” detection of oral ...
Veronika Shavlokhova, Christa Flechtenmacher, Sameena Sandhu, Michael Vollmer, Andreas Vollmer, Maximilian Pilz, Jürgen Hoffmann, Oliver Ristow, Michael Engel, Christian Freudlsperger   +9 more
doaj   +1 more source

Combining mKate2-Kv1.3 Channel and Atto488-Hongotoxin for the Studies of Peptide Pore Blockers on Living Eukaryotic Cells

Toxins, 2022
The voltage-gated potassium Kv1.3 channel is an essential component of vital cellular processes which is also involved in the pathogenesis of some autoimmune, neuroinflammatory and oncological diseases.
Nikita A. Orlov, Anastasia A. Ignatova, Elena V. Kryukova, Sergey A. Yakimov, Mikhail P. Kirpichnikov, Oksana V. Nekrasova, Alexey V. Feofanov   +6 more
doaj   +1 more source

Raman imaging of protein in a model cheese system

Journal of Spectral Imaging, 2020
Raman confocal microscopy is an increasingly useful technique when applied to food samples; it has the unique ability to interrogate the chemical structure, aligned with the same confocality capability that is available when using standard confocal ...
Elizabeth Nickless, Stephen E. Holroyd
doaj   +1 more source

Gingipain R1 and Lipopolysaccharide From Porphyromonas gingivalis Have Major Effects on Blood Clot Morphology and Mechanics

Frontiers in Immunology, 2020
Background:Porphyromonas gingivalis and its inflammagens are associated with a number of systemic diseases, such as cardiovascular disease and type 2 diabetes (T2DM).
J. Massimo Nunes, Tristan Fillis, Martin J. Page, Chantelle Venter, Ophélie Lancry, Douglas B. Kell, Douglas B. Kell, Douglas B. Kell, Ursula Windberger, Etheresia Pretorius   +9 more
doaj   +1 more source

Confocal laser speckle autocorrelation imaging of dynamic flow in microvasculature

Opto-Electronic Advances, 2022
Laser speckle imaging has been widely used for in-vivo visualization of blood perfusion in biological tissues. However, existing laser speckle imaging techniques suffer from limited quantification accuracy and spatial resolution.
E Du, Shuhao Shen, Anqi Qiu, Nanguang Chen   +3 more
doaj   +1 more source

Bonding effects of cleaning protocols and time-point of acid etching on dentin impregnated with endodontic sealer [PDF]

Restorative Dentistry & Endodontics, 2022
ObjectivesThis study aimed to investigate the bonding effects of cleaning protocols on dentin impregnated with endodontic sealer residues using ethanol (E) or xylol (X). The effects of dentin acid etching immediately (I) or 7 days (P) after cleaning were
Tatiane Miranda Manzoli, Joissi Ferrari Zaniboni, João Felipe Besegato, Flávia Angélica Guiotti, Andréa Abi Rached Dantas, Milton Carlos Kuga   +5 more
doaj   +1 more source

Development of Dual-Scale Fluorescence Endoscopy for In Vivo Bacteria Imaging in an Orthotopic Mouse Colon Tumor Model

Applied Sciences, 2020
Colorectal cancer is a representative cancer where early diagnosis and proper treatment monitoring are important. Recently, cancer treatment using bacteria has actively progressed and has been successfully monitored using fluorescence imaging techniques.
Su Woong Yoo, Dinh-huy Nguyen, Suhyeon Park, Hyeri Lee, Chang-Moon Lee, Changho Lee, Jung-Joon Min   +6 more
doaj   +1 more source

Performance comparison of aperture-less and confocal infrared microscopes

Journal of Spectral Imaging, 2019
We compared hyperspectral infrared raster maps and images for contrast, definition and resolution of the same samples recorded with a confocal microscope coupled with a synchrotron radiation source vs a Focal Plane Array (FPA) detector equipped ...
C. Sandt, Z. Dionnet, M. Toplak, E. Fernandez, R. Brunetto, F. Borondics   +5 more
doaj   +1 more source