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In confounding, the effect of the exposure of interest is mixed with the effect of another variable. It is important to identify relevant confounders and remove the confounding effect as much as possible. There are three criteria that need to be fulfilled to determine whether a variable could be considered a potential confounder. The first criterion is
Stralen, K.J. van +3 more
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Ethical review of real-world study
This article is devoted to an ethical review of planned real-world studies. The legal basis of such examinations has also been considered. Most real-world studies are non-interventional, so the ethical review of such studies is similar to that of ...
E. A. Volskaya +2 more
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Alcohol and its effects on aggression have been the subject of many discussions and research papers. Despite this fact, there is still a debate surrounding what it is exactly about alcohol that causes aggression. The current study sought to replicate the
Kristel De Groot
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Sensitivity analysis for causal effects with generalized linear models
Residual confounding is a common source of bias in observational studies. In this article, we build upon a series of sensitivity analyses methods for residual confounding developed by Brumback et al. and Chiba whose sensitivity parameters are constructed
Sjölander Arvid +2 more
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Background Prediction of mental disorders based on neuroimaging is an emerging area of research with promising first results in adults. However, research on the unique demographic of children is underrepresented and it is doubtful whether findings ...
Richard Gaus +4 more
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Analysts often use data-driven approaches to supplement their knowledge when selecting covariates for effect estimation. Multiple variable selection procedures for causal effect estimation have been devised in recent years, but additional developments ...
Talbot Denis, Beaudoin Claudia
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Confounding and confounders [PDF]
Confounding should always be addressed in studies concerned with causality. When present, it results in a biased estimate of the effect of exposure on disease. The bias can be negative - resulting in underestimation of the exposure effect - or positive, and can even reverse the apparent direction of effect.
openaire +3 more sources
Using sales data, information on antimicrobial consumption in animals is collected cumulatively across the European Union and member countries of the European Economic Area, which is documented and reported by every country and published within annual ...
Katharina Hommerich +4 more
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Administrative data in pediatric critical care research—Potential, challenges, and future directions
Heterogenous patient populations with small case numbers constitute a relevant barrier to research in pediatric critical care. Prospective studies bring along logistic barriers and—if interventional—ethical concerns.
Nora Bruns +7 more
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Clinical decisions in human and veterinary medicine should be based on the best available evidence. The results of primary research are an important component of that evidence base.
Jan M. Sargeant +2 more
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