Results 11 to 20 of about 793,872 (236)

Why do so many trials of vitamin D supplementation fail?

open access: yesEndocrine Connections, 2020
Our knowledge of vitamin D has come a long way since the 100 years it took for doctors to accept, between 1860 and 1890, that both sunlight and cod liver oil (a well-known folk remedy) cured and prevented rickets. Vitamins D2/D3 were discovered exactly a
Barbara J Boucher
doaj   +1 more source

Confounding and Confounding Control

open access: yes, 2022
AbstractCurrently, the classical, counterfactual, and structural confounding definitions, are simultaneously used in teaching or practice context of epidemiology. Despite the resemblance, the three definitions are different in many aspects. A unified theory of confounding and confounding control has not been established.
Shaolong Ren, Genming Zhao
openaire   +1 more source

Exchangeability of Measures of Association Before and After Exposure Status Is Flipped: Its Relationship With Confounding in the Counterfactual Model

open access: yesJournal of Epidemiology, 2023
Background: The counterfactual definition of confounding is often explained in the context of exchangeability between the exposed and unexposed groups.
Etsuji Suzuki   +2 more
doaj   +1 more source

Study Designs and Statistical Analyses for Biomarker Research

open access: yesSensors, 2012
Biomarkers are becoming increasingly important for streamlining drug discovery and development. In addition, biomarkers are widely expected to be used as a tool for disease diagnosis, personalized medication, and surrogate endpoints in clinical research.
Yasunori Sato   +2 more
doaj   +1 more source

Need for and practical interpretations of the person-year construct in neuropsychiatric research

open access: yesIndian Journal of Psychological Medicine, 2019
In observational studies, groups of interest may be carved out of predictors of interest. Thus, for example, if cardiovascular (CVS) health at age 50 years is the predictor of interest for dementia as the long-term outcome, groups of interest could ...
Chittaranjan Andrade
doaj   +1 more source

Genetic ancestry influences gene-environment interactions with sociocultural factors: Results from the Hispanic Community Health Study/Study of Latinos

open access: yesHGG Advances
Summary: Often, studies will aggregate all participants identified as Hispanic/Latino, despite genetic and environmental substructures, preventing the meaningful interrogation of the roles of genetics and environment in human health.
Jayati Sharma   +13 more
doaj   +1 more source

The Deductive Approach to Causal Inference

open access: yesJournal of Causal Inference, 2014
This paper reviews concepts, principles, and tools that have led to a coherent mathematical theory that unifies the graphical, structural, and potential outcome approaches to causal inference. The theory provides solutions to a number of pending problems
Pearl Judea
doaj   +1 more source

Confounding and Statistical Significance of Indirect Effects: Childhood Adversity, Education, Smoking, and Anxious and Depressive Symptomatology

open access: yesFrontiers in Psychology, 2017
The life course perspective, the risky families model, and stress-and-coping models provide the rationale for assessing the role of smoking as a mediator in the association between childhood adversity and anxious and depressive symptomatology (ADS) in ...
Mashhood Ahmed Sheikh
doaj   +1 more source

Targeted Maximum Likelihood Estimation for Dynamic and Static Longitudinal Marginal Structural Working Models

open access: yesJournal of Causal Inference, 2014
This paper describes a targeted maximum likelihood estimator (TMLE) for the parameters of longitudinal static and dynamic marginal structural models. We consider a longitudinal data structure consisting of baseline covariates, time-dependent intervention
Petersen Maya   +5 more
doaj   +1 more source

Third Variable Effects in Management Studies

open access: yesProblemy Zarządzania, 2016
The article’s aim is to explain the third variable effects in management studies –mediation, suppression, and confounding. Examples of these three types of the third variable effects are based on the European Social Survey (2012) data.
Anna Olga Kuźmińska
doaj   +1 more source

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