Results 41 to 50 of about 793,872 (236)
The Entry of Randomized Assignment into the Social Sciences
Journal of Causal Inference, 2019 Although the concept of randomized assignment in order to control for extraneous confounding factors reaches back hundreds of years, the first empirical use appears to have been in an 1835 trial of homeopathic medicine.
Jamison Julian C.
doaj +1 more source
Information Theoretic Causal Effect Quantification
Entropy, 2019 Modelling causal relationships has become popular across various disciplines. Most common frameworks for causality are the Pearlian causal directed acyclic graphs (DAGs) and the Neyman-Rubin potential outcome framework.
Aleksander Wieczorek, Volker Roth
doaj +1 more source
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Clinical Epidemiology, 2017 Merete Osler,1,2 Ida Kim Wium-Andersen,1,3 Martin Balslev Jørgensen,3 Terese Sara Høj Jørgensen,1,2 Marie Kim Wium-Andersen1 1Research Center for Prevention and Health, Rigshospitalet – Glostrup, Copenhagen University, Glostrup,
Osler M +4 more
doaj
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Transparent and complete reporting of confounding in observational research
JCPP Advances, 2022 Improved understanding of causal risk factors for child and adolescent mental health problems are dependent on observational research. Although confounding is a major limitation of observational research, this problem is widely ignored in the reporting ...
Henrik Larsson
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Frontiers in MedicineIntroductionThis study aims to discuss and assess the impact of three prevalent methodological biases: competing risks, immortal-time bias, and confounding bias in real-world observational studies evaluating treatment effectiveness.
Oksana Martinuka +11 more
doaj +1 more source
A Double machine learning trend model for citizen science data
Methods in Ecology and Evolution, 2023 Citizen and community science datasets are typically collected using flexible protocols. These protocols enable large volumes of data to be collected globally every year; however, the consequence is that these protocols typically lack the structure ...
Daniel Fink +10 more
doaj +1 more source