Results 71 to 80 of about 186,611 (326)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Large-Scale Vehicle Platooning: Advances and Challenges in Scheduling and Planning Techniques

Engineering, 2023
Through vehicle-to-vehicle (V2V) communication, autonomizing a vehicle platoon can significantly reduce the distance between vehicles, thereby reducing air resistance and improving road traffic efficiency.
Jing Hou, Guang Chen, Jin Huang, Yingjun Qiao, Lu Xiong, Fuxi Wen, Alois Knoll, Changjun Jiang   +7 more
doaj   +1 more source

Concurrent Optimization of Vehicle Dynamics and Powertrain Operation Using Connectivity and Automation

, 2020
Connected and automated vehicles (CAVs) provide the most intriguing opportunity to reduce energy consumption and travel delays. In this paper, we propose a two-level control architecture for CAVs to optimize (1) the vehicle's speed profile, aimed at ...
Mahbub, A M Ishtiaque, Malikopoulos, Andreas A.   +1 more
core   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

CPS architecture design for urban roadway intersections based on MBSE

Journal of Intelligent and Connected Vehicles
With the rapid growth of urbanization and the increasing demand for transportation, urban traffic congestion has become a hindrance to individuals’ travel experience.
Chen Wang, Xiaoping Ma, Limin Jia, Zheng Lai, Zhexuan Yang, Han Yan, Jing Zhao   +6 more
doaj   +1 more source

Safety and Efficiency of Intersections With Mix of Connected and Non-Connected Vehicles

IEEE Open Journal of Intelligent Transportation Systems, 2020
Connected and autonomous vehicles have been significantly studied. They are connected to a network and communicate by exchanging information with each other, so they can detect blind spots that cannot be recognized by non-connected (conventional ...
Koki Higashiyama, Kenta Kimura, Habibullah Babakarkhail, Kenya Sato   +3 more
doaj   +1 more source

A Control Method with Reinforcement Learning for Urban Un-Signalized Intersection in Hybrid Traffic Environment

Sensors, 2022
To control autonomous vehicles (AVs) in urban unsignalized intersections is a challenging problem, especially in a hybrid traffic environment where self-driving vehicles coexist with human driving vehicles.
Yanjun Shi, Yuanzhuo Liu, Yuhan Qi, Qiaomei Han   +3 more
doaj   +1 more source

Controlling Steering Angle for Cooperative Self-driving Vehicles utilizing CNN and LSTM-based Deep Networks

, 2019
A fundamental challenge in autonomous vehicles is adjusting the steering angle at different road conditions. Recent state-of-the-art solutions addressing this challenge include deep learning techniques as they provide end-to-end solution to predict ...
Fallah, Yaser P., Ozer, Sedat, Valiente, Rodolfo, Zaman, Mahdi   +3 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Wander Effect on Pavement Performance for Application in Connected and Autonomous Vehicles

Infrastructures, 2023
Connected and Autonomous Vehicles (CAV) will change how road engineers design road pavements because they can position themselves within a traffic lane, keeping their position in the lane more precisely than human-driven vehicles.
Jorge Pais, Paulo Pereira, Liseane Thives   +2 more
doaj   +1 more source