Results 41 to 50 of about 10,862 (262)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Decentralized Cooperative Lane-Changing Decision-Making for Connected Autonomous Vehicles
IEEE Access, 2016 In this paper, we proposed a decentralized cooperative lane-changing decision-making framework for connected autonomous vehicles, which is composed of three modules, i.e., state prediction, candidate decision generation, and coordination. In other words,
Jianqiang Nie +5 more
doaj +1 more source
Cooperative Roundabout Control Strategy for Connected and Autonomous Vehicles
Applied Sciences, 2022 Intersections in the urban network are potential sources of traffic flow inefficiency. Existing intersection control mostly adopts the “cross” flow pattern model, while the use of the roundabout circular flow pattern is rather sparse.
Chaojie Wang, Yu Wang, Srinivas Peeta
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Cooperative Lane-Changing Optimisation of Connected and Autonomous Vehicles in Freeway Merging Area
Promet (Zagreb)In freeway merging areas, vehicles exhibit flexibility in lane-changing manoeuvres to facilitate merging. However, the lack of effective communication among vehicles leads to inadequate coordination between mainline and ramp vehicles at the merge point ...
Xuling LIU, Xiaoning ZHANG
doaj +1 more source
PCM: A Positioning Calibration Mechanism for Connected Autonomous Vehicles
IEEE Access, 2020 Connected autonomous driving is considered as a potential way to improve traffic safety. However, when positioning information is delivered through network, the network time delay could result in additional positioning errors, which has been proved by ...
Yuhao Ling +4 more
doaj +1 more source
Vehicle-Life Interaction in Fog-Enabled Smart Connected and Autonomous Vehicles
IEEE Access, 2021 Traffic accidents have become a major issue for researchers, academia, government and vehicle manufacturers over the last few years. Many accidents and emergency situations frequently occur on the road.
Bushra Feroz +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source