Results 51 to 60 of about 179,061 (285)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Decentralized Cooperative Lane-Changing Decision-Making for Connected Autonomous Vehicles

IEEE Access, 2016
In this paper, we proposed a decentralized cooperative lane-changing decision-making framework for connected autonomous vehicles, which is composed of three modules, i.e., state prediction, candidate decision generation, and coordination. In other words,
Jianqiang Nie, Jian Zhang, Wanting Ding, Xia Wan, Xiaoxuan Chen, Bin Ran   +5 more
doaj   +1 more source

Vehicle-Life Interaction in Fog-Enabled Smart Connected and Autonomous Vehicles

IEEE Access, 2021
Traffic accidents have become a major issue for researchers, academia, government and vehicle manufacturers over the last few years. Many accidents and emergency situations frequently occur on the road.
Bushra Feroz, Amjad Mehmood, Hafsa Maryam, Sherali Zeadally, Carsten Maple, Munam Ali Shah   +5 more
doaj   +1 more source

Ethical and Social Aspects of Self-Driving Cars

, 2018
As an envisaged future of transportation, self-driving cars are being discussed from various perspectives, including social, economical, engineering, computer science, design, and ethics.
Dodig-Crnkovic, Gordana, Holstein, Tobias, Pelliccione, Patrizio   +2 more
core   +1 more source

Conditions for State and Control Constraint Activation in Coordination of Connected and Automated Vehicles

, 2020
Connected and automated vehicles (CAVs) provide the most intriguing opportunity to reduce pollution, energy consumption, and travel delays. In earlier work, we addressed the optimal coordination of CAVs using Hamiltonian analysis.
Mahbub, A M Ishtiaque, Malikopoulos, Andreas A.   +1 more
core   +1 more source

Vehicle and Powertrain Optimization for Autonomous and Connected Vehicles [PDF]

Mechanical Engineering, 2017
This article discusses the potential of using autonomous and connected vehicle (CV) technologies to save energy. It also focuses on the potential energy savings of internal combustion engine-based vehicles (ICVs) and hybrid electric vehicles (HEVs). An example of vehicle and powertrain co-optimization for HEV eco-approaching and departure is also given.
Yunli Shao, Mohd Azrin Mohd Zulkefli, Zongxuan Sun   +2 more
openaire   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Cooperative Lane-Changing Optimisation of Connected and Autonomous Vehicles in Freeway Merging Area

Promet (Zagreb)
In freeway merging areas, vehicles exhibit flexibility in lane-changing manoeuvres to facilitate merging. However, the lack of effective communication among vehicles leads to inadequate coordination between mainline and ramp vehicles at the merge point ...
Xuling LIU, Xiaoning ZHANG
doaj   +1 more source

Transfer Learning-Based Anomaly Detection System for Autonomous Vehicle

Engineering Proceedings, 2023
The advancements in technology have brought about significant changes in the automobile industry. A system that combines the control of a physical process with computing technology and communication networks is called a cyber–physical system (CPS).
Md. Humayun Kabir, Mohammad Nadib Hasan, Ahmad, Hassan Jaki   +3 more
doaj   +1 more source