Results 91 to 100 of about 2,130,336 (311)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Diverging pathomechanisms underlying collagen I-related and MBTPS2-related osteogenesis imperfecta: insights from patient-derived fibroblasts and iPSC-based modelling of bone

Frontiers in Endocrinology
Osteogenesis imperfecta (OI), characterised by low bone mass and bone fragility, is a heritable disorder with a heterogeneous genetic cause. Type I collagen is the most predominant type of collagen in the bone.
Pei Jin Lim, Giulio Marcionelli, Ceres Blättler, Silvan Gut, Silvan Gut, Marianne Rohrbach, Cecilia Giunta   +6 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The connective tissue connection [PDF]

Nature Structural & Molecular Biology, 1994
openaire   +2 more sources

Connective tissue (OckHS-408)

, 1964
Connective tissue -- Connective Tissue Spread -- Fibroblasts; HistiocytesStain: Hematoxylin and ...
Ockerman, Herbert W.
core  

Correlation Between Serum Tumor Marker Levels and Connective Tissue Disease-Related Interstitial Lung Disease

, 2021
Yunqi Bao,1 Wei Zhang,1 Dandan Shi,2 Weili Bai,1 Dongdong He,1 Dan Wang1 1Department of Rheumatology, Xi’an Fifth Hospital, Xian, 710000, Shaanxi, People’s Republic of China; 2Department of Radiology, Xi’an Fifth Hospital, Xian, 710000,
Zhang W, He D, Bao Y, Wang D, Shi D, Bai W   +5 more
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

A multicenter study of long-term outcomes of relapsing polychondritis in Iran

Scientific Reports
Relapsing polychondritis (RP) is a systemic immune mediated disease characterized by recurrent episodes of inflammation in various cartilage-rich areas. RP may cause extensive tissue destruction and is associated with significant morbidity and mortality.
Mehdi Jafarpour, Maryam Saberivand, Maryam Saemi, Maryam Sahebari, Seyedmostafa Seyedmardani, Mansour Salesi, Sarah Hosseinpoor, Tahereh Faezi, Kamal Esalatmanesh, Mehrzad Hajialilo, Sousan Kolahi, Zahra Myrfeizi, Alireza Khabbazi   +12 more
doaj   +1 more source

Connective tissue (OckHS-410)

, 1964
Connective tissue -- Connective Tissue Spread -- HistiocytesStain: Hematoxylin and ...
Ockerman, Herbert W.
core  

The influence of type I diabetes mellitus in periodontal disease induced changes of the gingival epithelium and connective tissue

, 2015
Periodontal disease constitutes the most frequent chronic diseases in human dentition. Bacterial plaque is the main etiologic agent, although it is the host immune response that causes periodontal tissue destruction.
Lorencini, M, Reis, JRR, Stach-Machado, DR, Carvalho, HF, Cagnon, VHA, Silva, JAF   +5 more
core   +1 more source