Results 61 to 70 of about 4,769,883 (431)

Extending the Relative Seriality Formalism for Interpretable Deep Learning of Normal Tissue Complication Probability Models [PDF]

arXiv, 2021
We formally demonstrate that the relative seriality model of Kallman, et al. maps exactly onto a simple type of convolutional neural network. This approach leads to a natural interpretation of feedforward connections in the convolutional layer and stacked intermediate pooling layers in terms of bystander effects and hierarchical tissue organization ...
arxiv  

Automated Discrimination of Pathological Regions in Tissue Images: Unsupervised Clustering vs Supervised SVM Classification [PDF]

, 2008
Recognizing and isolating cancerous cells from non pathological tissue areas (e.g. connective stroma) is crucial for fast and objective immunohistochemical analysis of tissue images.
A. Statnikov, A.C. Ruifrok, A.C. Ruifrok, A.K. Jain, C.Z. Cai, D. Anguita, D. Demandolx, E. Angelini, E.M. Brey, J. Platt, K.R. Muller, L. Wang, N. Malpica, V. Vapnik   +13 more
core   +1 more source

Human colon organoid differentiation from induced pluripotent stem cells using an improved method

FEBS Letters, Volume 599, Issue 6, Page 912-924, March 2025.
We compared established protocols to differentiate induced pluripotent stem cells into colon organoids and found that activation of bone morphogenetic protein 2 signaling induced gene expression of colon‐specific markers. Adenovirus‐mediated transduction of the transcription factors HOXD13 or SATB2 further enhanced colonic gene expression, suggesting ...
I‐Ting Lee, Yu Takahashi, Takashi Sasaki, Yoshio Yamauchi, Ryuichiro Sato   +4 more
wiley   +1 more source

Insights into the renal pathophysiology in Hermansky‐Pudlak syndrome‐1 from urinary extracellular vesicle proteomics and a new mouse model

FEBS Letters, Volume 599, Issue 7, Page 1055-1074, April 2025.
Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard, Bernadette R. Gochuico, Hadass Pri Chen, Christopher K. E. Bleck, Patricia M. Zerfas, Wendy J. Introne, William A. Gahl, May C. V. Malicdan   +7 more
wiley   +1 more source

The Genetics of Soft Connective Tissue Disorders.

Annual review of genomics and human genetics (Print), 2015
Over the last few years, the field of hereditary connective tissue disorders has changed tremendously. This review highlights exciting insights into three prototypic disorders affecting the soft connective tissue: Ehlers-Danlos syndrome, pseudoxanthoma ...
O. Vanakker, B. Callewaert, F. Malfait, P. Coucke   +3 more
semanticscholar   +1 more source

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, Volume 599, Issue 8, Page 1094-1112, April 2025.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source

Use of Patterned Collagen Coated Slides to Study Normal and Scleroderma Lung Fibroblast Migration

Scientific Reports, 2017
Systemic sclerosis (SSc) is a spreading fibrotic disease affecting the skin and internal organs. We aimed to model pathogenic fibroblast migration in SSc in order to identify enhancing factors, measure the effect of migrating cells on underlying ...
Bahja Ahmed Abdi, Henry Lopez, Sarah Karrar, Elisabetta Renzoni, Athol Wells, Angela Tam, Oseme Etomi, J. Justin Hsuan, George R. Martin, Xu Shiwen, Christopher P. Denton, David Abraham, Richard Stratton   +12 more
doaj   +1 more source

Correlation of plasma interleukin-18 concentration and severity of renal involvement and disease activity in systemic lupus erythematosus [PDF]

Journal of Nephropathology, 2016
Background: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by activation of T and polyclonal B lymphocytes. IL-18 was originally identified as a factor which enhances IFN-γ production and is a potent inducer of the ...
Mohammad Reza Jafari-Nakhjavani, Sima Abedi-Azar, Babak Nejati   +2 more
doaj   +1 more source

Ocular involvement in rheumatic diseases

Rheumatology, 2023
Rheumatic diseases are associated with a significant decline in quality of life, which is not only related to the progression of the underlying disease but also to the development of coexisting conditions.
Iwona Dankiewicz- Fares, Daniel Jeka, Tacjana Barczyńska   +2 more
doaj   +1 more source

Tissue Engineering of Skin Regeneration and Hair Growth [PDF]

arXiv, 2021
Many people suffering from skin disorders such as chronic wounds, non-healing ulcers, and diabetic ulcers need skin repair and regeneration. Aside from the diseases listed above, the industry needed a skin rejuvenation system and regeneration for cosmetic purposes.
arxiv